Adverse effects of antifungal therapies in invasive fungal infections: review and meta-analysis.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
S B GiroisB G P Revol

Abstract

Amphotericin B is the main therapeutic agent for the treatment of invasive fungal infections; however, it is associated with significant toxicities that limit its use. Other systemic antifungal agents have been developed to improve tolerability while maintaining the efficacy profile of conventional amphotericin B. Fifty-four studies involving 9,228 patients were assessed for the frequency of adverse effects of the main systemic antifungal agents. While the results suggest that liposomal amphotericin B is the least nephrotoxic of the lipid formulations (14.6%), that conventional amphotericin B is the most nephrotoxic (33.2%), and that itraconazole is the most hepatotoxic (31.5%), the lack of standard definitions of antifungal-related adverse effects limits the validity of these results. Furthermore, heterogeneous patient pools and differing protocols make it difficult to draw direct comparisons between studies. With the advent of newer classes of systemic antifungal agents, future trials should conform to definitions that are universally applicable and clinically relevant to allow for such comparisons and to enable evidence-based decision-making.

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·F MeunierO Ringdén
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·R J Walker, G G Duggin
Aug 1, 1994·The American Journal of Medicine·D W DenningA Catanzaro
May 30, 1994·Statistics in Medicine·J L WallerC Z Garrison
May 1, 1994·The Journal of Infection·R J Hay
Nov 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A OppenheimS Kusne
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W Hiemenz, T J Walsh
Aug 1, 1996·The American Journal of Medicine·E J AnaissieG P Bodey
Nov 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J AnaissieG P Bodey
May 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C ViscoliM Congiu
Apr 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P F Troke
May 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P PhillipsS Ioannou
Oct 24, 1997·The Annals of Pharmacotherapy·R P RappM E Evans
Mar 28, 1998·Antimicrobial Agents and Chemotherapy·E J AnaissieL A Pietrelli
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T J WalshE J Anaissie
Aug 26, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H WhiteC B Miller
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Wong-BeringerB J Guglielmo
Nov 18, 1998·Bone Marrow Transplantation·O RingdénN Jacobsen
Dec 30, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M EllisB Vandercam
Jul 8, 1999·Chemotherapy·R HerbrechtA Cavalier
Aug 26, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A I PoppD Armstrong
Aug 26, 1999·The Pediatric Infectious Disease Journal·T J WalshS J Chanock

❮ Previous
Next ❯

Citations

Sep 19, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Mariana Montenegro SilvaCarlos Eduardo Vergani
Jul 3, 2013·Antimicrobial Agents and Chemotherapy·Jessica A EdwardsChad A Rappleye
Nov 21, 2014·Expert Opinion on Drug Safety·Aditya K GuptaKelly A Foley
Jun 13, 2009·Current Medical Research and Opinion·Russell E Lewis
Mar 23, 2013·Journal de mycologie médicale·E R RodriguesR C L R Pietro
Apr 14, 2007·Dermatologic Clinics·Alexandra Y ZhangBoni E Elewski
Jan 4, 2012·The American Journal of Medicine·Dimitrios P Kontoyiannis
Dec 2, 2008·Expert Opinion on Pharmacotherapy·Ioanna FiliotiEmmanuel Roilides
Jul 22, 2016·Journal of Pharmacology & Pharmacotherapeutics·Jamie L Wagner, Allison M Bell
May 21, 2016·Journal of Clinical Pharmacology·Maria Clara Padovani de SouzaAdriano Max Moreira Reis
May 19, 2016·Anais Brasileiros De Dermatologia·Rogério Rodrigo RamosMauricio da Silva Baptista
Dec 9, 2016·Expert Opinion on Drug Safety·Ioannis KyriakidisAndreas H Groll
Dec 12, 2017·TheScientificWorldJournal·Francislene J MartinsNádia R B Raposo
Apr 25, 2018·Antimicrobial Agents and Chemotherapy·Ritam SidhuRoyce H Johnson
May 31, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mitchell S BuckleyMary T Martin
Feb 19, 2010·The Cochrane Database of Systematic Reviews·Christopher C BlythMichael H Bennett
Jun 4, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·UNKNOWN ALSUNTANGLED GROUP
Jun 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chelsea N PowersWilliam N Setzer
Dec 14, 2018·Journal of Fungi·Nikolaos Spernovasilis, Diamantis P Kofteridis
Jun 1, 2007·The Journal of Antimicrobial Chemotherapy·Philipp AltmannsbergerStefan W Krause
Feb 14, 2019·Journal of Fungi·Savvas PapachristouEmmanuel Roilides
Feb 24, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·K J G BrouwersR A Tupker
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Krishnan Ganesh PrasathShunmugiah Karutha Pandian
Apr 4, 2007·Pediatrics·Christopher C BlythTracey A O'Brien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.