Adverse effects of antiparkinsonian drugs

Drugs
J D Parkes

Abstract

In the last decade neurohormone replacement therapy with levodopa has revolutionised the treatment of Parkinson's disease. At the same time the use of amantadine and dopamine-like ergot drugs has developed, although there is still a place for anticholinergic drugs, not in use for a century. These advances have resulted in the availability of many different drugs to treat Parkinsonism with different pharmacological actions. It is now usually possible to control disability, at least in the initial stages of disease, although sometimes at the expense of frequent and disabling side effects. In most cases these result from the widespread distribution of cholinergic and dopaminergic systems inside and outside the brain and the non-selective action of therapeutic agents on these different systems. Despite the recent division of dopamine receptors into D1 and D2 classes, no selective dopamine-like antiparkinsonian drugs are known. The practical treatment of Parkinsonism depends on accurate knowledge of the side effects as well as therapeutic effects of many different drugs, and requires titration of individually determined dosages in different patients to achieve the optimum response. This is usually determined by dose-limiting side ef...Continue Reading

Citations

Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·P WormsK Biziere
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·P M CarveyH L Klawans
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·D S JanowskyJ C Gillin
Dec 1, 1984·Lancet·R G Brown, C D Marsden
Jun 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·P SoliveriC D Marsden
Apr 21, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C Colosimo, M De Michele
Feb 1, 1990·Psychological Medicine·R G Brown, B MacCarthy
Dec 1, 1982·Ophthalmology·G H Van RensM F Brihaye-Van Geertruyden
Jul 15, 2015·Chemical Society Reviews·Tegan P Stockdale, Craig M Williams
Nov 1, 1984·Comprehensive Psychiatry·M H el-Defrawi, T J Craig
Jul 1, 1991·Journal of the American Geriatrics Society·J L Cummings
Dec 1, 1984·British Journal of Clinical Pharmacology·J S ShindlerJ D Parkes
Feb 1, 1988·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T A HurwitzK Waterman

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