PMID: 6886255Aug 1, 1983

Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children

The Journal of Allergy and Clinical Immunology
D E Schuller

Abstract

The role of antihistamines in the therapy of bronchial asthma has remained controversial. Early studies suggested a possible aggravation of symptoms but more recent studies implied their safety. Ten asthmatic children who reported a feeling of chest tightness and subsequent wheezing after taking a preparation containing brompheniramine maleate were studied in addition to 10 control asthmatic children who reported no such adverse effect. All children were only intermittently symptomatic and did not require constant bronchodilator therapy. They were well at the time of the study. Challenges were performed with the antihistamine alone (4 mg of brompheniramine maleate), a decongestant-antihistamine combination (4 mg of brompheniramine maleate, 5 mg of phenylephrine HCl, 5 mg of phenylpropanolamine HCl), and a placebo. Results indicated a statistically significant decrease in pulmonary function in the study children when challenged with the antihistamine and decongestant-antihistamine preparation but not when challenged with the placebo. The 10 control asthmatic children did not exhibit this phenomenon and premedication with theophylline prevented the decrease in pulmonary function in the study group. Therefore a subset of asthmatic...Continue Reading

References

Dec 1, 1996·The Journal of Allergy and Clinical Immunology·L M Du Buske
Aug 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J Rimmer, M K Church
Jan 1, 1997·Allergy·A Malick, J A Grant
May 16, 2006·Treatments in Respiratory Medicine·Andrew M Wilson
Aug 17, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanni RossettiMichael F Hofer
Feb 1, 1986·Postgraduate Medicine·D E Schuller, D Turkewitz
Jan 1, 1987·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C Collins-Williams

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