Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial

Journal of Pregnancy
D MannaertsY Jacquemyn

Abstract

To compare the incidence of nausea, vomiting, and arterial hypotension between carbetocin and oxytocin to prevent haemorrhage after caesarean section (CS). A randomized controlled trial in term pregnant women undergoing planned CS. Groups were randomized to carbetocin or oxytocin. Blood pressure (BP), heart rate, presence of nausea/vomitus, and need for vasopressors were evaluated throughout surgery. Preoperative and postoperative haemoglobin and haematocrit levels were compared. Fifty-eight women were randomized (carbetocin n = 32; oxytocin n = 26). Both medications had hypotensive effect, difference in BP for carbetocin versus oxytocin: systolic (14.4 ± 2.4 mmHg versus 8.5 ± 1.8 mmHg); diastolic (7.8 ± 1.6 mmHg versus 8.9 ± 3.0 mmHg) without significant difference between the drugs (p = 0.1 and p = 0.7). Both groups had similar needs for vasopressors. The presence of nausea was not rare, but the difference was not statistically significant (p = 0.4). Average blood loss was slightly lower in the carbetocin group but not statistically significant (p = 0.8). In planned CS, a possible clinical significant lower incidence of nausea after carbetocin was noted but this was not statistically significant. There were no differences reg...Continue Reading

References

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Citations

Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Dec 7, 2018·PharmacoEconomics Open·Karen PickeringTracy E Roberts
Oct 24, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Agnieszka WsolAgnieszka Cudnoch-Jedrzejewska

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Clinical Trials Mentioned

ISRCTN95504420

Software Mentioned

SPSS21

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