Adverse effects of direct acting antiviral-based regimens in chronic hepatitis C patients: a Brazilian experience

International Journal of Clinical Pharmacy
Thalia MedeirosAndrea Alice da Silva

Abstract

Background Direct-acting antivirals (DAA) are currently used for the treatment of chronic hepatitis C (HCV). However, few studies describe the adverse effects (AE) associated with DAA therapy in "real-word" cohorts. Aim To evaluate AE in Brazilian chronic HCV patients after DAA-therapy. Setting A reference center for hepatitis treatment in Rio de Janeiro, Brazil. Methods An observational "real-world" study was conducted with 102 chronic HCV patients undergoing DAA therapy for 12 or 24 weeks. The self-reported AE were correlated with cirrhosis status, genotype, age, current therapeutic schemes and comorbidities. Serious AE were also investigated. Main outcome measure Frequency of AE during DAA therapy. Results Overall, mean ± SD age was 60.9 ± 9.4 years, 67% were females, HCV-genotype 1 was the most prevalent (81%) and 74% were cirrhotic. Moreover, all patients reached sustained virological response. About 90% of patients reported at least one AE associated with current treatment, with a mean of 2.7 symptoms per patient. The most frequently reported AE were fatigue (43%), headache (42%), neuropsychiatric symptoms (30%) and nausea (26%). Furthermore, hemoglobin < 12 mg/dL was the most frequent (38%) laboratory abnormality observe...Continue Reading

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Citations

May 8, 2018·Journal of Clinical Pharmacy and Therapeutics·T MedeirosJ R Almeida
Nov 7, 2019·Pharmacoepidemiology and Drug Safety·Camille Nigri CursinoSabrina Calil-Elias
May 17, 2019·Clinical Obstetrics and Gynecology·Robert S Egerman
Dec 5, 2019·Arquivos De Gastroenterologia·Andréa Delfino TorresCarla Vitola Gonçalves
Jul 7, 2018·Mediators of Inflammation·Geórgia Nascimento SaraivaAndrea Alice Silva
Feb 4, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Isabella Patrícia Lima SilvaHeloisa Ramos Lacerda

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