Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy

Experimental and Clinical Psychopharmacology
Mark D LindnerFrederic Machet

Abstract

Amitriptyline and gabapentin are the primary treatments for painful diabetic neuropathy (PDN), and it is clear that they produce beneficial effects, but there are questions about these treatments that have not been adequately addressed. For example, although there is a growing consensus that the therapeutic effects of amitriptyline in pain patients are independent of its effects on mood, it is not clear that amitriptyline has specific and direct effects on pain. There is also a fairly broad consensus that gabapentin is safe and well tolerated, but the side-effect profile of gabapentin has not been adequately assessed in pain populations. The rat streptozotocin (STZ) model of PDN was used (a) to assess the effects of amitriptyline on objective, quantitative measures of tactile allodynia, a common type of pain in PDN patients, and (b) to assess the side effects of gabapentin using measures of motor/ambulatory and cognitive function. Amitriptyline did not attenuate STZ-induced mechanical allodynia, even after chronic administration of high doses. Gabapentin produced robust anti-allodynic effects but also produced deficits in tests of motor/ambulatory and cognitive functions. The present experiments suggest that the beneficial effe...Continue Reading

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Citations

Feb 21, 2014·Pharmacological Reports : PR·Magdalena ZychowskaJoanna Mika
Dec 8, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lizu XiaoDeren Zhang
Sep 9, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Wenhua XiaoGary J Bennett
Oct 13, 2018·Neuropharmacology·Nicholas AtwalChristopher W Vaughan
Sep 28, 2020·Neuroscience and Biobehavioral Reviews·Ana Margarida CunhaHugo Leite-Almeida

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