May 1, 1997

Adverse effects of interrupting precordial compression during cardiopulmonary resuscitation

Critical Care Medicine
Y SatoJ Bisera


In the current operation of automated external defibrillators, substantial time may be consumed for a "hands off" interval during which precordial compression is discontinued to allow for automated rhythm analyses before delivery of the electric countershock. The effects of such a pause on the outcomes of cardiopulmonary resuscitation were investigated. Prospective, randomized, controlled animal study. Research laboratory. Male Sprague-Dawley rats. Ventricular fibrillation was electrically induced in 25 Sprague-Dawley rats. After 4 mins of untreated ventricular fibrillation, precordial compression was begun and continued for 6 mins. Animals were then randomized to receive an immediate defibrillation shock or the defibrillation attempt was delayed for intervals of 10, 20, 30, or 40 secs. Immediate defibrillation restored spontaneous circulation in each instance. When defibrillation was delayed for 10 or 20 secs, spontaneous circulation was restored in three of five animals in each group. After a 30-sec delay, spontaneous circulation was restored in only one of five animals (p < .05). No animal was successfully resuscitated after a 40-sec delay (p < .01). With increasing delays, 24- and 48-hr survival rates were correspondingly r...Continue Reading

Mentioned in this Paper

Ventricular Fibrillation
Basic Cardiac Life Support
Electroversion Therapy
Heart Diseases
Survival Rate
Rats, Holtzman
Rats, Laboratory

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