Adverse effects of intravenously administered drugs used in anaesthetic practice

Drugs
R S Clarke

Abstract

Adverse effects of intravenous anaesthetic drugs may be divided into local and general effects. The former include venous sequelae ranging from soreness on palpation on the day after the injection to thrombosis of the whole venous system of the arm. Frequency of venous sequelae for water-soluble anaesthetics 5 to 10%; drugs sparingly soluble in water are similar in this regard when solubilised in 'Cremophor EL'. Diazepam or etomidate dissolved in propylene glycol can produce venous reactions in about 25% of patients on the 3rd day and more by the 15th day if given directly into the vein, and are really only acceptable when injected in an infusion. The general adverse effects of anaesthetic agents include excitatory effects, as well as those on the cardiovascular and respiratory systems which are almost unavoidable. Excitatory effects are diminished by suitable premedication, and the cardiovascular and respiratory effects can be minimised by low dosage and slow administration. Cardiovascular effects of the muscle relaxants are also unavoidable with the drugs presently available, but further research should provide drugs with greater selectivity. More troublesome are the hypersensitivity reactions which occur with both the induct...Continue Reading

Citations

May 1, 1986·Canadian Anaesthetists' Society Journal·G C Moudgil
Dec 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S A EcoffD J Steward
Sep 1, 1986·Canadian Anaesthetists' Society Journal·J E Tetzlaff, M D Gellman
Mar 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J H GaudyJ F Boitier
Jul 1, 1984·Canadian Anaesthetists' Society Journal·P WestacottZ Jancelewicz
Dec 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·O R HungM MacSween
Apr 21, 1984·Lancet·J FreneyH Leclerc
Apr 21, 1984·Lancet·J W Dundee
Jan 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J A Roelofse, J J Joubert
Aug 18, 2004·Journal of Cataract and Refractive Surgery·M Pierre PangBetty McMullin
Feb 1, 1987·Anaesthesia·J M PuseyE S Assem
Jul 6, 2005·Pharmacology & Therapeutics·Esa R Korpi, Saku T Sinkkonen
Jan 1, 1993·Annales Françaises D'anesthèsie Et De Rèanimation·G MaroneB Mazzarella
Sep 18, 2015·Anesthesia and Analgesia·John W Sear, Talmage D Egan
Apr 23, 2015·Anesthesia and Analgesia·Markus W Hollmann, John W Sear
Jan 1, 1985·Annales Françaises D'anesthèsie Et De Rèanimation·R S Clarke
Apr 20, 2007·Allergy·D G EboW J Stevens
Sep 13, 2003·Anaesthesia·K Jenkins, A B Baker
Apr 1, 1985·Anaesthesia·J WatkinsR S Clarke
May 16, 2017·European Journal of Medicinal Chemistry·Pavel Y SavechenkovKarol S Bruzik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.