Mar 28, 2003

Adverse effects of non-steroidal anti-inflammatory drugs. A prevalence study in Austria

Wiener klinische Wochenschrift
Gernot KolarzFranz Singer

Abstract

Gastrointestinal side effects are the limiting factor in the prescription of non-steroidal antirheumatic drugs (NSAID). However, there are no recent data from Austria. The aim of this prevalence study was therefore to assess the gastrointestinal risk from NSAID in Austria. A total of 1347 patients were observed in an outpatient setting between March 2000 and February 2001. Side effects from NSAID were documented by questionnaire at two time points with a mean interval of 31 days. Documented data were analysed descriptively using an explorative strategy. The prevalence of side effects was compared to data from literature. Side effects were reported by 18.1% of the patients, severe gastro-intestinal complications (ulcer, bleeding, perforation) were diagnosed in 0.7%. Prescription of effective GI-protection (proton pump inhibitors, misoprostole, famotidin in high dose) was seen in only one third of the patients at risk. The prevalence of severe gastrointestinal side effects by NSAIDs assessed in our study was clearly lower than the prevalence reported in the Anglo-American literature. This may be due to a different prescription behaviour: about 75% of the patients took Diclofenac, lbuprofen or Meloxicam, drugs which have a very lo...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Proton Pump Inhibitors
Anti-Ulcer Agent
Gastric Ulcer
Proton Pump Inhibitors [MoA]
Antirheumatic Agents
Analgesics, Anti-Inflammatory
Nonsteroidal Anti-inflammatory Drug [EPC]
Anti-Inflammatory Agents, Non-Steroidal
Adverse Effects

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