Adverse effects of prolactin in rodents and humans: breast and prostate cancer

Journal of Psychopharmacology
Philip W HarveyChristopher J Springall

Abstract

Drugs and chemicals shown to induce mammary carcinogenesis in the rat/rodent via prolactin excess have traditionally been argued to pose little or no risk to humans in a regulatory toxicology context. The basis for this assumption is reviewed and placed into context with new evidence in humans that prolactin may be a tumour promoter in the breast and prostate. This evidence includes epidemiology, patient studies involving endocrine evaluation and molecular biology in human cells. It is concluded that hyperprolactinaemia is associated with an increase in breast cancer risk in both post and premenopausal women, that rat carcinogenicity studies are predictive of the human response, and that in a regulatory toxicology context prolactin-induced mammary tumours from nongenotoxic drugs and chemicals are an adverse effect that should not be ignored. More evidence is required concerning prostate cancer risk but molecular biology indicates that prolactin also induces prostate cell proliferation and inhibits apoptosis, which are similar to the responses observed in breast cancer cells.

References

Oct 1, 1975·British Journal of Cancer·C W WelschC Brooks
Apr 1, 1992·International Journal of Epidemiology·D Y WangR R Millis
Jun 1, 1991·Environmental Health Perspectives·L S GoldL Bernstein
Apr 1, 1986·European Journal of Cancer & Clinical Oncology·D Y WangR D Rubens
Jan 29, 1987·The New England Journal of Medicine·D L Kleinberg
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·W HoltkampD von Heyden
Dec 1, 1981·International Journal of Cancer. Journal International Du Cancer·H G KwaJ Cuzick
Aug 1, 1995·Endocrinology·J MershonN Ben-Jonathan
Sep 28, 1998·Pharmacology & Therapeutics·B K Vonderhaar
Feb 11, 1999·Journal of Toxicology and Environmental Health. Part a·J T StevensL Wetzel
Apr 15, 1999·Journal of the National Cancer Institute·S E HankinsonF E Speizer
May 18, 1999·Biochemical and Biophysical Research Communications·D A FavyD J Bernard-Gallon
Jul 20, 1999·Molecular and Cellular Endocrinology·V GoffinP A Kelly
Oct 12, 1999·Endocrine-related Cancer·B K Vonderhaar
Jan 1, 1997·Journal of Mammary Gland Biology and Neoplasia·R Das, B K Vonderhaar
Oct 18, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J M BhatavdekarT I Trivedi
Nov 9, 2000·Drug and Chemical Toxicology·J C O'ConnorJ C Cook
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·F Van CoppenolleN Prevarskaya
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·P StattinR Kaaks
Jan 5, 2002·Molecular Endocrinology·Matthew D SchroederLinda A Schuler
Feb 5, 2002·Annual Review of Physiology·Vincent GoffinPaul A Kelly
May 11, 2002·Current Hypertension Reports·Ehud GrossmanUri Goldbourt
Jul 20, 2002·Trends in Endocrinology and Metabolism : TEM·Nira Ben-JonathanMichael Zinger
Dec 10, 2002·Archives of General Psychiatry·Philip S WangJerry Avorn
Feb 18, 2003·Endocrine Reviews·Charles V ClevengerLinda A Schuler
Feb 26, 2003·European Urology·Alain RuffionPauline R M Dobson
Jun 18, 2003·Endocrinology·Fiona G RobertsonChristopher J Ormandy
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·François M Lalonde, Michael Myslobodsky
Jan 23, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M CohenDorothy Patton
Jun 24, 2004·British Journal of Cancer·C M PerksJ M P Holly
Aug 21, 2004·Molecular Endocrinology·Jennifer H GutzmanLinda A Schuler
Sep 18, 2004·Cancer Research·Shelley S TworogerSusan E Hankinson
Apr 9, 2005·Endocrine Reviews·Vincent GoffinPaul A Kelly
May 12, 2005·Schizophrenia Research·Susanne Oksbjerg DaltonChristoffer Johansen

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Citations

Jul 19, 2012·Journal of Physiology and Biochemistry·Pilar SánchezEsperanza Ortega
Jul 6, 2010·The Lancet Oncology·Louise M HowardGraham Thornicroft
Oct 15, 2010·Journal of Psychopharmacology·Richard HodgsonChris J Bushe
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Romina MancinelliEugenio Gaudio
Mar 7, 2012·World Journal of Surgery·Yao-Tsung YehShen-Nien Wang
Aug 22, 2009·Schizophrenia Research·Chris J BusheRichard E Hodgson
Nov 6, 2009·The Journal of Investigative Dermatology·Ewan A LanganRalf Paus
Feb 14, 2013·Internal Medicine Journal·S T Pattison, B R McLaren
Mar 8, 2011·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Marc DE HertStefan Leucht
Sep 3, 2011·Journal of Applied Toxicology : JAT·Adam Hargreaves, Johannes Harleman
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Jari HaukkaJari Tiihonen
Mar 14, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
Mar 19, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Virunya S BhatJ Caroline English
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Dana L ShueyAlan Roberts
Jun 23, 2016·Arhiv za higijenu rada i toksikologiju·Lucija PerharičJernej Drofenik
Mar 29, 2013·Journal of Psychopharmacology·Allan H YoungKlaus Wiedemann
Oct 6, 2011·Toxicologic Pathology·Philip W Harvey
May 1, 2010·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Michaela Skopek, Puthenpurackal Manoj
Aug 16, 2008·Journal of Psychopharmacology·Dora Kohen, Hiram Joseph Wildgust
Apr 4, 2014·Molecular Endocrinology·Robert J Marano, Nira Ben-Jonathan
Oct 1, 2009·Physiological Reviews·Carmen ClappGonzalo Martínez De La Escalera
Aug 25, 2020·Journal of Applied Toxicology : JAT·Matthew J LeBaronDarrell R Boverhof
Dec 22, 2010·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Chris J Bushe, Richard Hodgson
Dec 22, 2020·Journal of Clinical Psychopharmacology·Tahir RahmanEric J Lenze

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