Adverse effects of the antiangiogenic agent angiostatin on the healing of experimental colonic anastomoses

Annals of Surgical Oncology
Elisabeth A te VeldeInne H Borel Rinkes

Abstract

Antiangiogenic cancer therapy is likely to be administered long term for sustained suppression of tumor outgrowth. Surgeons will encounter more patients undergoing such therapy. Therefore, it is essential to know the effects of antiangiogenic agents on physiological angiogenesis, as occurs during the healing of colonic anastomoses. Angiostatin was generated from human plasma and administered continuously. In 38 mice, the right colon was anastomosed after transection: group 1 (n = 13), anastomotic healing under angiostatin treatment from surgery until death (day 7); group 2 (n = 13), phosphate-buffered saline controls. For healing on discontinuation of treatment, group 3 (n = 6) received angiostatin treatment preceding surgery during 4 days; group 4 (n = 6) included controls. On day 7, all mice were inspected for signs of anastomotic leakage. Bursting pressure measurements were performed to test anastomotic strength. Neovascularization was assessed semiquantitatively by immunohistochemistry. Mice treated with angiostatin postoperatively showed significantly more signs of leakage, more adhesions, and peritonitis. One mouse died on day 5. Five mice had paralytical ileus. The bursting pressure in group 1 was 135 +/- 20 mm Hg, versu...Continue Reading

References

Dec 1, 1991·Pharmacology & Therapeutics·F Arnold, D C West
Oct 1, 1990·Diseases of the Colon and Rectum·T Hendriks, W J Mastboom
Apr 19, 1995·Journal of the National Cancer Institute·E E VoestJ Folkman
Jun 1, 1996·Nature Medicine·M S O'ReillyJ Folkman
Jun 1, 1997·The Surgical Clinics of North America·F J Thornton, A Barbul
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·L Claesson-WelshJ Folkman
May 11, 1999·Journal of the American College of Surgeons·J PicklemanR Gamelli
Oct 3, 1999·The British Journal of Surgery·J M HendriksE Eyskens
May 19, 2000·The Journal of Surgical Research·A C BergerS K Libutti
Jul 13, 2000·The European Journal of Surgery = Acta Chirurgica·T A DrixlerI H Borel Rinkes

❮ Previous
Next ❯

Citations

Feb 27, 2004·Biochimica Et Biophysica Acta·Jarmila D W van der Bilt, Inne H M Borel Rinkes
Jul 11, 2009·Expert Review of Anticancer Therapy·Gerald M Higa, Jame Abraham
May 19, 2009·The Journal of Surgical Research·Niels KomenJohan F Lange
Nov 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F C S EngJ J Knox
Aug 25, 2005·Journal of Surgical Oncology·Frank A ScappaticciHerbert Hurwitz
Oct 3, 2003·Journal of Thrombosis and Haemostasis : JTH·E A te VeldeJ C M Meijers
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroki IshikawaKatsumi Eguchi
Jan 17, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mahtab Bahramsoltani, Johanna Plendl
Feb 19, 2008·The British Journal of Surgery·A R JohnM C Eggo
Mar 7, 2006·Microsurgery·C Kristian EnestvedtBlair A Jobe
Dec 3, 2009·Journal of Surgical Oncology·Isabelle DeshaiesDominique Elias
Oct 4, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Nikolaos SymeonidisAthanasios Sakantamis
Mar 25, 2015·Cancer Epidemiology·Sarah A AronerSusan E Hankinson
Jun 10, 2014·Prostaglandins & Other Lipid Mediators·Takao TsujiKazutetsu Aoshiba
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert A BurgerSharon X Liang
Sep 25, 2007·Journal of Dental Research·C R DassP F M Choong
Mar 11, 2016·International Journal of Colorectal Disease·Joanna W A M BosmansNicole D Bouvy
Sep 22, 2005·Digestive Surgery·Maartje LosInne H M Borel Rinkes
Aug 19, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·C Kristian EnestvedtBlair A Jobe
Aug 8, 2008·Annals of Surgical Oncology·Charlotte F J M PeetersTheo J M Ruers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.