Adverse effects of topical papaverine on auditory nerve function

Acta neurochirurgica
Geraldine M ChadwickRichard J Pollard

Abstract

Papaverine hydrochloride is a direct-acting vasodilator used to manage vasospasm during various neurosurgical operations. Transient cranial nerve dysfunction has been described in a few cases with topical papaverine. This study supports previous reports and provides neurophysiological evidence of an adverse effect on the auditory nerve. We conducted a retrospective review of 70 consecutive microvascular decompression operations and studied those patients who received topical papaverine for vasospasm. Topical papaverine was used as a direct therapeutic action to manage vasospasm in a total of 11 patients. The timing of papaverine application and ongoing operative events was reviewed relative to changes in neurophysiological recordings. Brainstem auditory evoked potentials (BAEPs) were routinely used to monitor cochlear nerve function during these operations. A temporal relationship was found between topical papaverine and BAEP changes leading to complete waveform loss. The average temporal delay between papaverine and the onset of an adverse BAEP change was 5 min. In 10 of 11 patients, BAEP waves II/III-V completely disappeared within 2 to 25 min after papaverine. Eight of these 10 patients had complete loss of BAEP waveforms wi...Continue Reading

References

Feb 1, 1992·Hearing Research·K A OhlsénE Hultcrantz
Dec 1, 1990·Neurosurgery·D E McDonnellP M Klara
Apr 1, 1994·Surgical Neurology·M B Pritz
Apr 15, 1999·American Journal of Otolaryngology·G E KimW P Hong
Jul 21, 1999·Journal of Neurosurgery·M R McLaughlinD K Resnick
Oct 13, 2001·Surgical Neurology·J R CarhuapomaD F Hanley
Jan 7, 2003·Neurologia Medico-chirurgica·Erhard W LangNicholas W C Dorsch
Jul 26, 1958·Journal of the American Medical Association·J L POOLT A FLETCHER
Nov 6, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Krzysztof MorawskiBrenda L Lonsbury-Martin
Jun 27, 2006·Journal of Neurosurgical Anesthesiology·K R Madhusudan ReddyV R Sastry Kolluri

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Citations

Jul 5, 2011·Journal of Neurosurgery·Colleen M MoranChristoph N Seubert
Nov 16, 2010·Acta neurochirurgica·Prashant ChittiboinaBharat Guthikonda
May 17, 2011·Journal of the American Academy of Dermatology·Hsien-Yi Chiu, Tsen-Fang Tsai
Aug 15, 2020·Frontiers in Cellular Neuroscience·Juan Carlos AlvaradoJosé M Juiz

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