Adverse effects reported in the use of gastroesophageal reflux disease treatments in children: a 10 years literature review

British Journal of Clinical Pharmacology
Shlomi CohenFrancis B Mimouni

Abstract

Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present article was to review the reported adverse effects of pharmacological agents used in the treatment of paediatric GERD. We conducted this review using the electronic journal database Pubmed and Cochrane database systematic reviews using the latest 10-year period (1 January 2003 to 31 December 2012). Our search strategy included the following keywords: omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole, rantidine, cimetidine, famotidine, nizatidine, domperidone, metoclopramide, betanechol, erythromycin, baclofen, alginate. We used Pubmed's own filter of: 'child: birth-18 years'. All full articles were reviewed and we only included randomized controlled trials retrieved from our search. We addressed a summary of our search on a drug-by-drug basis with regard to its mechanism of action and clinical applications, and reviewed all of the adverse effects reported and the safety profile of each drug. Adverse effects have been reported in...Continue Reading

Associated Clinical Trials

Jan 9, 2017·Shucheng ZhangShucheng Zhang

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Citations

May 2, 2016·The Journal of Pediatrics·Jonathan L SlaughterSudarshan R Jadcherla
Aug 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Kornilia NikakiDaniel Sifrim
Dec 15, 2017·Archives of Disease in Childhood·Pauline De Bruyne, Shinya Ito
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May 22, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Yvan VandenplasSilvia Salvatore
Dec 12, 2019·European Journal of Clinical Pharmacology·Su-Yeon YuSamantha A Hollingworth
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Sep 26, 2019·Frontiers in Pediatrics·David Avelar RodriguezEamonn Martin Quigley
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Apr 14, 2021·Journal of Pediatric Gastroenterology and Nutrition·Rok OrelNikhil Thapar
Feb 20, 2021·Journal of Pediatric Gastroenterology and Nutrition·Jonathan O'Donnell, Usha Krishnan
Sep 14, 2021·Acta Paediatrica·Noora HelinLaura Merras-Salmio
Dec 13, 2016·Pediatrics·Ricardo A Quinonez, Eric R Coon

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