Adverse Event Profile Associated with Prolonged Use of CentriMag Ventricular Assist Device for Refractory Cardiogenic Shock

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Marisa R CevascoHiroo Takayama

Abstract

Several studies have investigated early outcomes with a surgical short-term ventricular assist device (VAD), but little is known about adverse event profile during prolonged support with a surgical short-term VAD. This is a retrospective analysis of 161 patients who received a CentriMag ventricular assist system (Abbott Laboratories, Abbott Park, IL) at our institution between January 2007 and June 2014. Device-related adverse events include major bleeding, infection, and stroke incidents occurring during CentriMag support. Cumulative frequency of adverse events was estimated by Nelson's nonparametric method. One hundred and forty-three (88.8%) patients had biventricular VAD and 18 (11.2%) had isolated left VAD. Median duration of support was 16 days (interquartile range [IQR]: 10-29). Mortality was 24.8% and 1 year overall survival is 51.8% (95% CI: 43.3-59.5%). The most common adverse event during support was major bleeding (n = 121, 75.1%). Ninety-five (59.0%) developed major infections such as pneumonia and urinary tract infection. Sixteen patients (10%) experienced stroke. Cumulative data analysis showed that stroke and reoperation caused by bleeding were rare beyond 30 days, whereas infection and nonsurgical bleeding even...Continue Reading

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Citations

May 22, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Inderjeet BhatiaTimmy Wing-Kuk Au
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Mar 3, 2021·Revista Española De Cardiología·Miguel Solla-BucetaEduardo Barge-Caballero

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