Adverse Events And Emergency Department Opioid Prescriptions In Adolescents.

Health Affairs
Christopher M WorshamMichael L Barnett

Abstract

Understanding the risks associated with opioid prescription in adolescents is critical for informing opioid policy, but the risks are challenging to quantify given the lack of randomized trial data. Using a regression discontinuity design, we exploited a discontinuous increase in opioid prescribing in the emergency department (ED) when adolescents transition from "child" to "adult" at age eighteen to estimate the effect of an ED opioid prescription on subsequent opioid-related adverse events. We found that adolescent patients just over age eighteen were similar to those just under age eighteen, but they were 9.7 percent more likely to be prescribed an opioid and 12.6 percent more likely to have an adverse opioid-related event, defined as overdose, diagnosis of opioid use disorder, or long-term opioid use, within one year. We estimated a 14.1 percent increased risk for an adverse outcome when "adults" just over age eighteen were prescribed opioids that would not have been prescribed if they were just under age eighteen and considered "children." Our results suggest that differences in care provided in pediatric versus adult care settings may be important to understanding prescribers' roles in the opioid epidemic.

References

Mar 17, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·A H ThompsonR J Dyck
Jan 18, 2007·Annals of Internal Medicine·Bridget A MartellDavid A Fiellin
Aug 21, 2010·American Journal of Public Health·Cynthia I CampbellMichael Von Korff
Sep 1, 2006·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Valerie F Reyna, Frank Farley
Oct 27, 2015·JAMA : the Journal of the American Medical Association·Benjamin W FriedmanE John Gallagher
Oct 28, 2015·Pediatrics·Richard MiechKennon Heard
Feb 15, 2016·Annals of Emergency Medicine·Megan M ButlerMichael S Lyons
Oct 21, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christopher RowePhillip O Coffin
Feb 16, 2017·The New England Journal of Medicine·Michael L BarnettAnupam B Jena
Mar 17, 2017·MMWR. Morbidity and Mortality Weekly Report·Anuj ShahBradley C Martin
Aug 23, 2017·Pediatrics·Amy Peykoff HardinUNKNOWN COMMITTEE ON PRACTICE AND AMBULATORY MEDICINE
Jan 27, 2018·Annals of Emergency Medicine·Sarah AxeenMichael Menchine
Jul 18, 2018·Pediatrics·Cecilia P ChungWayne A Ray
Nov 30, 2018·The New England Journal of Medicine·Timothy J LaytonAnupam B Jena
Oct 3, 2019·Pediatrics·Cornelius B GroenewaldWilliam C Van Cleve
Jul 3, 2020·JAMA : the Journal of the American Medical Association·Matthew L Maciejewski, Anirban Basu

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