Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France

BJU International
Caroline Prot-BertoyeFrench Cystinuria Group

Abstract

To evaluate medical treatments, in terms of adverse events (AEs) and therapeutic goals, in a large series of patients with cystinuria. Data from 442 patients with cystinuria were recorded retrospectively. Crystalluria was studied in 89 patients. A mixed-effects logistic regression model was used to estimate how urine pH, specific gravity and cysteine-binding thiols (CBT) correlate with risk of cystine crystalluria. Alkalizing agents and CBT agents were given to 88.8% (n = 381) and 55.3% (n = 238) of patients, respectively. Gastrointestinal AEs were reported in 12.3%, 10.4% and 2.6% of patients treated with potassium bicarbonate, potassium citrate and sodium bicarbonate, respectively (P = 0.008). The percentages of patients who experienced at least one AE with tiopronin (24.6%) and with D-penicillamine (29.5%) were similar (P = 0.45). Increasing urine pH and decreasing urine specific gravity significantly reduced the risk of cystine crystalluria, whereas D-penicillamine and tiopronin treatments did not reduce this risk (odds ratio [OR] 1 for pH ≤6.5; OR 0.52 [95% confidence interval {95% CI} 0.28-0.95] for 7.0 <pH ≤7.5, P = 0.03; OR 0.26 [95% CI 0.13-0.53] for 7.5 < pH ≤8.0, P <0.001; OR 1 for specific gravity ≤1.005 OR 5.76 [95...Continue Reading

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Citations

Sep 13, 2020·Kidney International·Aude ServaisUNKNOWN Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) and eUROGEN
Feb 11, 2021·Nutrients·Roswitha SienerAlbrecht Hesse
Apr 4, 2021·Journal of Clinical Medicine·Toshifumi TakahashiHitoshi Yamada
Mar 4, 2020·Néphrologie & thérapeutique·Marie CourbebaisseMichel Daudon
Apr 30, 2021·Néphrologie & thérapeutique·Caroline Prot-BertoyeMarie Courbebaisse
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Simona KovaříkováKateřina Vrbová
Nov 24, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Viola D'AmbrosioPietro Manuel Ferraro

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