Adverse events associated with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia

Expert Opinion on Drug Safety
Massimo BrecciaGiuliana Alimena

Abstract

Tyrosine kinase inhibitors (TKIs) drastically changed the outcome of patients affected by chronic myeloid leukemia, allowing long-term improved overall survival and deep molecular responses. Areas covered: In this review, all the related and "off target" side effects of different TKIs are reported and reviewed including their pathogenesis, and associated predisposing factors are discussed. Expert Opinion: Appropriate identification of adverse events and classification according to CTC scale is required during therapy with TKI, considering the impact on the long-term quality of life. Specific evaluation and stratification of comorbidities and cardiovascular risk profile at baseline is suggested in order to better tailor individualized treatment strategy and identify patients who require strict monitoring of risk factors during treatment.

References

Jul 31, 1999·Annals of Internal Medicine·S FaderlH M Kantarjian
May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A HahnUNKNOWN IRIS Investigators
Jun 5, 2003·Seminars in Hematology·Martin Sattler, James D Griffin
Oct 10, 2003·The New England Journal of Medicine·John M Goldman, Junia V Melo
Jan 7, 2004·Nature Reviews. Molecular Cell Biology·Oliver Hantschel, Giulio Superti-Furga
Jul 24, 2004·Hematology/oncology Clinics of North America·Junia V Melo, Michael W N Deininger
Jul 25, 2006·Nature Medicine·Risto KerkeläThomas Force
Jan 9, 2007·Nature Medicine·Alan HatfieldPaul Richard Pilot
Sep 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfonso Quintás-CardamaJorge Cortes
May 23, 2008·Leukemia Research·Antonio Luiz RibeiroNelma C D Clementino
Aug 30, 2008·Blood·Jamie J O'BrienRichard P Phipps
Sep 8, 2009·Acta Oncologica·George S OrphanosAlexandros G Ardavanis
Oct 14, 2009·Blood·Gianantonio RostiUNKNOWN GIMEMA CML Working Party
Mar 23, 2011·Journal of the National Cancer Institute·Carlo Gambacorti-PasseriniDong-Wook Kim
May 4, 2011·American Journal of Hematology·Karl J AichbergerPeter Valent
Aug 5, 2011·Journal of the National Cancer Institute·Philipp Le CoutrePeter Valent
Aug 13, 2011·American Heart Journal·Richa Agarwal, Mardi Gomberg-Maitland
Mar 14, 2012·Blood·Krisztina FutosiAttila Mócsai
Mar 28, 2012·Circulation·David MontaniMarc Humbert
Nov 30, 2012·The New England Journal of Medicine·Jorge E CortesMoshe Talpaz
Apr 10, 2013·OncoTargets and Therapy·Massimo BrecciaGiuliana Alimena
Nov 5, 2013·The New England Journal of Medicine·J E CortesUNKNOWN PACE Investigators

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