Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature

PLoS Neglected Tropical Diseases
Philip J BudgeGary J Weil

Abstract

WHO's Global Programme to Eliminate Lymphatic Filariasis (LF) uses mass drug administration (MDA) of anthelmintic medications to interrupt LF transmission in endemic areas. Recently, a single dose combination of ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB) was shown to be markedly more effective than the standard two-drug regimens (DEC or IVM, plus ALB) for achieving long-term clearance of microfilaremia. To provide context for the results of a large-scale, international safety trial of MDA using triple drug therapy, we searched Ovid Medline for studies published from 1985-2017 that reported adverse events (AEs) following treatment of LF with IVM, DEC, ALB, or any combination of these medications. Studies that reported AE rates by treatment group were included. We reviewed 162 published manuscripts, 55 of which met inclusion criteria. Among these, 34 were clinic or hospital-based clinical trials, and 21 were community-based studies. Reported AE rates varied widely. The median AE rate following DEC or IVM treatment was greater than 60% among microfilaremic participants and less than 10% in persons without microfilaremia. The most common AEs reported were fever, headache, myalgia or arthralgia, fatigue, and m...Continue Reading

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References

May 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·M L EberhardP J Lammie
Aug 1, 1992·Annals of Tropical Medicine and Parasitology·P C Fan
Jun 1, 1992·The American Journal of Tropical Medicine and Hygiene·G DreyerA Coutinho
Sep 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·M SabryM E Kilpatrick
Mar 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·D G AddissH C Spencer
Jan 11, 1991·The American Journal of Tropical Medicine and Hygiene·F O RichardsH C Spencer
Apr 19, 1990·The New England Journal of Medicine·E A OttesenS P Tripathy
May 1, 1969·The American Journal of Tropical Medicine and Hygiene·F CiferriJ F Kessel
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·F PartonoS Oemijati
Jul 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·G DreyerD Addiss
May 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·L D AndradeG Dreyer
Feb 1, 1994·The American Journal of Tropical Medicine and Hygiene·J P Moulia-PelatJ L Cartel
Mar 1, 1994·The American Journal of Tropical Medicine and Hygiene·A D CoutinhoI Moura
Dec 1, 1993·The American Journal of Tropical Medicine and Hygiene·J KazuraM Alpers
Apr 1, 1993·The American Journal of Tropical Medicine and Hygiene·J W MakS Ambu
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·S L HakimJ W Mak
Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·J Figueredo-SilvaG Dreyer
Jul 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W MeyrowitschW H Makunde
Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M IsmailA S Dissanaike
Jan 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·J NorõesD Addiss
Apr 1, 1997·Tropical Medicine & International Health : TM & IH·W C CaoJ D Habbema
May 9, 1998·The American Journal of Tropical Medicine and Hygiene·M BoussinesqJ P Chippaux
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M IsmailA S Dissanaike
Oct 9, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·G DreyerJ Norões
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·M HaarbrinkM Yazdanbakhsh
Jul 27, 2001·Parasite Immunology·M J TaylorK Bilo
Aug 9, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M M IsmailW K Balasooriya

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Citations

Jun 28, 2019·Current Topics in Medicinal Chemistry·Puvvada Kalpana Murthy
Nov 27, 2019·The American Journal of Tropical Medicine and Hygiene·Vijesh Sreedhar KuttiattJambulingam Purushothaman
Jan 22, 2020·The Journal of Antimicrobial Chemotherapy·Miriam NavarroAlejandro Krolewiecki
Jun 22, 2021·Journal of Molecular Structure·Tean ZaheerMaría Del Pilar Rodríguez Torres
Sep 6, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Moussa SangareYaya Ibrahim Coulibaly

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Methods Mentioned

BETA
MDA

Clinical Trials Mentioned

NCT02899936

Software Mentioned

Ovid
DEC
Stata

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