Adverse events in IBD therapy: the 2018 update

Expert Review of Gastroenterology & Hepatology
Sandra M QuezadaRaymond K Cross

Abstract

Crohn's disease and ulcerative colitis affect an increasing number of patients, and utilization of immune suppressant and biologic therapies is also increasing. These agents are linked to adverse events ranging from mild nuisance symptoms to potentially life-threatening complications including infections and malignancies. Areas covered: This review provides an updated discussion on adverse events associated with immunomodulator, anti-TNF-α, anti-integrin, and anti-IL 12/IL-23 antibody therapies. In addition, we review the risk profile of the currently widely available infliximab biosimilar medication. Expert commentary: Providers should engage in risk-benefit discussion with information specific to each medication discussed, and consider individualized risk factors when selecting therapeutic agents. Drug monitoring and shared decision-making results in more personalized medical management of inflammatory bowel disease.

References

Aug 1, 1989·Clinical Pharmacology and Therapeutics·L LennardR M Weinshilboum
Apr 1, 1974·Teratology·R G Skalko, M P Gold
Apr 1, 1972·American Journal of Obstetrics and Gynecology·D G JohnsC L Vogel
Feb 2, 1995·The New England Journal of Medicine·B G FeaganM Hopkins
Dec 1, 1993·Gastroenterology·P MunkholmV Binder
Mar 31, 1998·Journal of the American Academy of Dermatology·H H RoenigkM Lebwohl
Apr 7, 1999·Scandinavian Journal of Gastroenterology·H H RasmussenF H Steffensen
Oct 7, 2000·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·T F Schaible
Feb 24, 2001·Scandinavian Journal of Gastroenterology·J BelaicheE Louis
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
May 21, 2003·Annals of Internal Medicine·Hyon J KwonM Miles Braun
Jun 18, 2003·The American Journal of Gastroenterology·Marla C DubinskyEric A Vasiliauskas
Jun 24, 2003·The American Journal of Gastroenterology·Adam CheifetzScott Plevy
Apr 3, 2004·Inflammatory Bowel Diseases·Carlton W ThomasWilliam J Sandborn
Oct 9, 2004·Inflammatory Bowel Diseases·J M Calbo MayoM Vicente Gutierrez
Oct 12, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bruce E SandsUNKNOWN ACCENT II Study
Mar 11, 2005·Journal of Clinical Gastroenterology·Pedram J Enayati, Konstantinos A Papadakis
Jun 24, 2005·Inflammatory Bowel Diseases·Faten N Aberra, Gary R Lichtenstein
Dec 13, 2005·The New England Journal of Medicine·Paul RutgeertsJean Frédéric Colombel
Dec 24, 2005·Autoimmunity·Piercarlo Sarzi-PuttiniAndrea Doria
Aug 22, 2006·Alimentary Pharmacology & Therapeutics·M A M BerendsJ P H Drenth
Apr 28, 2007·Scandinavian Journal of Infectious Diseases·Umut KalyoncuA Ihsan Ertenli
Jul 20, 2007·The New England Journal of Medicine·William J SandbornUNKNOWN PRECISE 1 Study Investigators
Jul 20, 2007·The New England Journal of Medicine·Stefan SchreiberUNKNOWN PRECISE 2 Study Investigators
Sep 4, 2007·The American Journal of Gastroenterology·Omid A ShayeTram T Tran
Feb 26, 2008·Gastroenterology·Murat TorunerLaurence J Egan
Jul 12, 2008·Alimentary Pharmacology & Therapeutics·A AnsariJ Sanderson
Jul 17, 2008·The British Journal of Dermatology·L L A LecluseM A de Rie
Oct 17, 2008·The Journal of Dermatological Treatment·Justin M KoJoseph F Kerbleski
Dec 5, 2008·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Apr 9, 2009·The American Journal of Gastroenterology·Jean-Frédéric ColombelParvez M Mulani
May 7, 2009·Current Opinion in Gastroenterology·Corey A Siegel
Jun 18, 2009·The American Journal of Gastroenterology·Josh MarehbianWilliam J Sandborn
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Corey A SiegelBruce E Sands
Aug 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon

❮ Previous
Next ❯

Citations

Apr 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiangqi LiMingjun Gu
May 27, 2020·Current Opinion in Gastroenterology·Ashley Vachon, Frank I Scott
Feb 25, 2020·Reviews on Recent Clinical Trials·Tiziana LarussaFrancesco Luzza
Jun 24, 2020·Current Medical Research and Opinion·Roberta RobertiGiovambattista De Sarro
Apr 9, 2019·Human Antibodies·Donatella VolpattiMauro Spanghero
Mar 3, 2021·Food Research International·Ana Paula da Fonseca MachadoMário Roberto Maróstica Júnior
Jul 13, 2020·Biochemical Pharmacology·Gabor TajtiRaymond S Norton
Apr 7, 2019·Trends in Molecular Medicine·Sruthi Vijaya Retnakumar, Sylviane Muller
Aug 29, 2021·Cell Death and Differentiation·Stella KarstenUlrika Warpman Berglund

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved