PMID: 8971293Dec 1, 1996Paper

Adverse events in patients treated with 5-aminosalicyclic acid: 1993-1994 pharmacovigilance report for Pentasa in France

Alimentary Pharmacology & Therapeutics
P MarteauC Devaux

Abstract

The incidence of the side-effects of 5-aminosalicylic acid (5-ASA) in clinical practice is not known. To present the safety reports on the use of Pentasa in France. Pentasa-related adverse events were recorded from 1 January 1993 to 31 December 1994. Spontaneous reports to Ferring S.A. came from physicians or pharmacovigilance regional centres. In 1993 and 1994, 51 and 79 adverse events were reported; the estimated gross incidence was 6.6 and 9.0 per million days of therapy. Detailed information was obtained 64% of cases in 1993 and 53% in 1994. Adverse events with a high likelihood of causalty included five cases of diarrhoea, 14 cases of pancreatitis, seven cases of liver abnormalities, seven of blood dyscrasias, two cases of renal insufficiency (one of which was in a fetus), and eight of cardiac disorders including three myocarditis. Pentasa seldom has adverse effects. The majority of the adverse events do not seem to be dose-related. Clinicians should be aware of exceptional but severe adverse events including pancreatitis, cardiac disorders, blood dyscrasias and renal insufficiency.

Citations

Jan 24, 2007·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Sep 16, 2010·Inflammatory Bowel Diseases·Konstantinos OikonomouSpiros Potamianos
Jul 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M ResbeutT D N'Guyen
Feb 1, 2004·Clinics in Colon and Rectal Surgery·Uma Mahadevan
Jul 29, 2000·Journal of Clinical Gastroenterology·F Goldstein, A J DiMarino
Feb 24, 2001·Journal of Clinical Gastroenterology·F Goldstein
Feb 24, 2001·Journal of Clinical Gastroenterology·P J MargettsI Alexopoulou
Sep 23, 2010·Southern Medical Journal·Brian T FowlerMuhammad Bilal
Dec 20, 2003·Gut·G D'Haens, A A van Bodegraven
Feb 16, 2005·Digestion·Pascal JuilleratPierre Michetti
Feb 2, 2008·Digestion·Pascal JuilleratPierre Michetti
Jun 17, 2011·Nephron. Clinical Practice·Konstantinos A OikonomouSpyros P Potamianos
May 10, 2011·Case Reports in Gastroenterology·Yuichi ShimodateMasafumi Nomura
Sep 8, 2000·Clinical Pharmacokinetics·M De Vos
Mar 8, 2013·World Journal of Gastroenterology : WJG·Rita SlimRaymond Sayegh
Dec 3, 2010·Journal of Crohn's & Colitis·Erdem AkbalFatma Kılıç
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Stefan SchreiberGary R Lichtenstein
Mar 7, 2012·Expert Review of Clinical Pharmacology·Maggie Ham, Alan C Moss
Mar 21, 2007·Expert Opinion on Drug Safety·Alan C Moss, Mark A Peppercorn
Oct 22, 2008·Gastroenterología y hepatología·Javier P GisbertJosé Maté
Jan 20, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gary R LichtensteinWilliam J Sandborn
Aug 16, 2005·Alimentary Pharmacology & Therapeutics·L Beaugerie, D S Pardi
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CamusP Marteau
Jun 5, 2004·Gastroenterology Clinics of North America·Laura E Harrell, Stephen B Hanauer
Feb 17, 2015·Gastroenterology Research and Practice·Cristiana PerrottaEmilio Clementi
Jun 30, 2014·World Journal of Pediatrics : WJP·Iva HojsakSanja Kolaček
Nov 5, 2015·Inflammatory Bowel Diseases·Arvind I SrinathSohail Z Husain
Dec 21, 2002·The American Journal of Gastroenterology·William J Sandborn
Jun 27, 2014·Clinical Medicine Insights. Gastroenterology·Maria CappelloPiero Luigi Almasio
Nov 15, 2006·The American Journal of Gastroenterology·Flavia D MendesKeith D Lindor
May 12, 1998·The American Journal of Gastroenterology·D S PardiJ T McCarthy
May 31, 2008·The American Journal of Gastroenterology·Guillaume Savoye
Nov 30, 2000·The American Journal of Gastroenterology·R BhidayasiriD R Sokos
Jan 28, 2010·Journal of Clinical Gastroenterology·Mario Guslandi
Jun 14, 2017·Expert Opinion on Drug Safety·Edoardo Troncone, Giovanni Monteleone
Aug 29, 2006·World Journal of Gastroenterology : WJG·Katja S RothfussKlaus R Herrlinger
Oct 13, 2006·World Journal of Gastroenterology : WJG·A A van Bodegraven, Chris J J Mulder
Oct 31, 2020·Gastroenterology Clinics of North America·Richa Chibbar, Alan C Moss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M J WorldD J Rainford
© 2021 Meta ULC. All rights reserved