Apr 18, 2019

Adverse events in patients with leprosy on treatment with thalidomide

Revista Da Sociedade Brasileira De Medicina Tropical
Paula Lana de Miranda DrummondCristiane Aparecida Menezes de Pádua

Abstract

Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic. A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Odds ratios with 95% confidence intervals were estimated via logistic regression. Peripheral neuropathy symptoms and deep vein thrombosis (DVT) were the most common AEs reported. Although women of reproductive age used contraceptives, <50% of patients reported using condoms. Polypharmacy was associated with all endpoints, except DVT. Pharmacovigilance is crucial to prevent harmful thalidomide-associated AEs.

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Mentioned in this Paper

Prevalence Studies
Deep Vein Thrombosis
Leprostatic Agents
Logistic Regression
Evaluation
Adverse Event
Illiteracy
Thalidomide
Cross-Sectional Studies
Peripheral Neuropathy

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