Adverse events of smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes in the Food and Drug Administration Adverse Event Reporting System, 2004-2016

SAGE Open Medicine
Yumi MotookaMitsuhiro Nakamura

Abstract

Several smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes are widely used. We evaluated the adverse events related to smoking cessation treatments and electronic cigarettes in the US Food and Drug Administration Adverse Event Reporting System database. We analyzed reports of adverse events associated with smoking cessation treatment and electronic cigarettes terms dated between January 2004 and December 2016. We used the reporting odds ratio with 95% confidence intervals to detect a signal for each adverse event. In total, 8,867,135 reports in the Food and Drug Administration Adverse Event Reporting System database were analyzed. The numbers of adverse events for nicotine replacement therapy (transdermal, buccal, oral, and respiratory administration) were 1673, 1016, 425, and 56, respectively. Nicotine replacement therapy (transdermal, buccal, and oral) demonstrated adverse events of nausea, nicotine dependence, and dizziness. For nicotine (transdermal) exposure, the top 5 adverse events reported were nausea (149 cases, reporting odds ratio: 2.28 (95% confidence interval: 1.92-2.69)), dizziness (132 cases, reporting odds ratio: 3.04 (95% confidence int...Continue Reading

References

May 20, 1998·Nature·M P Epping-JordanA Markou
May 10, 2002·Pharmacoepidemiology and Drug Safety·Eugène P van PuijenbroekAntoine C G Egberts
Oct 7, 2004·The Medical Clinics of North America·Susan M ZbikowskiJennifer B McClure
May 8, 2008·JAMA : the Journal of the American Medical Association·Michael C Fiore, Carlos Roberto Jaén
Apr 10, 2009·Pharmacoepidemiology and Drug Safety·A Bate, S J W Evans
Mar 17, 2010·Psychopharmacology·Marc S BerridgeMark V Boswell
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrea R VansickelThomas E Eissenberg
Jul 6, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sonal SinghCurt D Furberg
Aug 2, 2011·International Journal of Clinical Practice·J FouldsA Berg
Nov 11, 2011·PloS One·Thomas J MooreSonal Singh
Jan 11, 2012·Addiction·Andrea R VansickelThomas Eissenberg
Apr 5, 2012·Chest·Lindsay McCauleyDanielle Hosmer
Apr 25, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Maciej L GoniewiczLeon Kosmider
Aug 3, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ii-Lun Chen
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Kate CahillTim Lancaster
Sep 14, 2013·Lancet·Christopher BullenNatalie Walker
Oct 24, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·Sandri Rachelle van StadenLynton Tempest Hazelhurst
Apr 16, 2014·Tobacco Control·Ling YangElizabeth L Durmowicz
May 13, 2014·International Journal of Environmental Research and Public Health·Riccardo PolosaCristina Russo
May 14, 2014·Circulation·Rachel GranaStanton A Glantz
May 14, 2014·Circulation·Rachel A GranaStanton Glantz
Aug 2, 2014·Therapeutic Advances in Drug Safety·Konstantinos E Farsalinos, Riccardo Polosa
Aug 27, 2014·Circulation·Aruni BhatnagarUNKNOWN American Heart Association Advocacy Coordinating Committee, Council on Cardiovascular and Stroke Nursing, Council on Clinica
Dec 3, 2014·Preventive Medicine·Charlotta Pisinger, Martin Døssing
Apr 25, 2015·Tobacco Control·Elizabeth L DurmowiczIi-Lun Chen
Sep 4, 2015·Annual Review of Medicine·Judith J Prochaska, Neal L Benowitz
Mar 11, 2016·Tobacco Control·Susan F Rudy, Elizabeth L Durmowicz
Jul 15, 2016·Preventive Medicine Reports·My Hua, Prue Talbot
Dec 5, 2016·American Journal of Preventive Medicine·Allison M GlasserAndrea C Villanti
Dec 18, 2016·Respiratory Research·Riccardo PolosaCosimo Marcello Bruno

❮ Previous
Next ❯

Citations

Apr 6, 2019·Journal of Clinical Pharmacy and Therapeutics·Jan M KitzenRobert B Raffa
Jan 4, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Anthony Todd
Jan 5, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mohammed ImranDarshan Kharadi
Jun 3, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Greg CarneyColin R Dormuth
Jan 4, 2020·Journal of Medical Internet Research·My HuaPrue Talbot
Mar 1, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Dimitra MakryniotiGeorge Lagoumintzis
Jan 5, 2022·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ameen AmanianAmanda C Hu

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
medical procedure

Software Mentioned

JMP
MedDRA
FileMaker Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.