Oct 4, 2003

Adverse experience in childhood as a developmental risk factor for altered immune status in adulthood

International Journal of Behavioral Medicine
P G SurteesKay-Tee Khaw

Abstract

Compelling evidence is now available that adverse childhood experiences are associated with adult pathology. However, understanding of the pathways and mechanisms underlying these associations is limited. Participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk, UK (EPIC-Norfolk), aged 40 to 80 years, provided an opportunity to investigate the hypothesis that adverse experience in childhood is associated with peripheral leukocyte count in adulthood in the context of a large-scale population-based cohort study. White blood cell counts were available from 11,367 participants and, after a mean interval of 44 months, from 11,857 at a second health check. A self-completion questionnaire that included the assessment of adverse experience during childhood was administered during the interval between health checks. Associations were observed between early adverse experiences and lymphocyte counts at both health checks. Lifestyle factors accounted for about half of this association. Caution is needed in the interpretation of these findings that require replication but they may be seen to aid understanding of the mechanisms through which early environmental exposures act.

  • References61
  • Citations17

Citations

Mentioned in this Paper

Biochemical Pathway
Cessation of Life
White Blood Cell Count Procedure
Adverse Event
Leukocytes
Delayed Onset Post-Traumatic Stress Disorder
Hostility
Analysis, Event History
Mood (Psychological Function)
Lymphocyte Count Measurement

About this Paper

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine
Dana A GleiMaxine Weinstein
Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Stacey N DoanGary W Evans
© 2020 Meta ULC. All rights reserved