Adverse hemodynamic and ultrastructural changes in dog hearts subjected to protein-calorie malnutrition

American Heart Journal
R M AbelW A Gay


In the absence of thiamine deficiency, the specific effects of protein-calorie malnutrition on left ventricular (L.V.) function are unknown. Mature beagle dogs of both sexes were subjected to a hypocaloric, nitrogen-poor diet which resulted in a weight loss of approximately 40% after seven weeks. Following preparation of this nutritional model, myocardial contractility was assessed acutely by obtaining isovolumetric L.V. contractions on cardiopulmonary bypass at constant heart rate, mean aortic pressure, and at a wide range of end-diastolic volumes. These changes were compared to a matched group of animals which were normally fed. There were consistent decreases in L.V. compliance in malnourished animals compared with normals; indices of ventricular contractility per se (L.V. dp/dt, force-velocity relations, peak developed L.V. pressure) were also diminished in the experimental animals. Myocardial concentration of glycogen was diminished in malnourished compared to control animals. Light and electron microscopic examination confirmed the presence of myofibrillar atrophy in the presence of interstitial edema. These results suggest that protein-calorie malnutrition seriously interferes with normal L.V. function in the experimenta...Continue Reading


Jul 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·K C Ko, R R Paradise
Oct 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·K C Ko, R R Paradise
Nov 1, 1969·The British Journal of Nutrition·G A AlleyneB L Nichols
Feb 1, 1968·The Journal of Clinical Investigation·T P GrahamE Braunwald
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Jul 1, 1964·The Journal of Clinical Investigation·H J LEVINE, N A BRITMAN
Apr 1, 1952·British Heart Journal·J HIGGINSONJ F MURRAY


Jan 1, 1980·Journal of Neural Transmission·M A RossiR S Costa
Jun 1, 1997·Disease-a-month : DM·B A Mizock, S Troglia
Jun 11, 1991·Journal of Cardiac Surgery·K S Ulicny, L F Hiratzka
Mar 11, 1992·Chest·K S Ulicny, L F Hiratzka
Mar 31, 2015·Experimental Animals·Kazuhiko TakamatsuTakahito Nishikata
Jul 1, 1987·The Journal of Surgical Research·R C KuykendallW E Walker
Oct 10, 2015·European Eating Disorders Review : the Journal of the Eating Disorders Association·Carolina A EscuderoGeorge G S Sandor
May 1, 2008·Life Sciences·Ana Elisa ToscanoRaul Manhaes-de-Castro
Aug 8, 2013·The International Journal of Eating Disorders·Serap OflazHuseyin Oflaz
Apr 1, 1992·International Journal of Cardiology·S S KothariT K Patel
Mar 1, 1983·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·D S Moodie, E Salcedo
Oct 17, 2015·PloS One·Christian FabiansenThomas Thymann
Apr 30, 2005·International Journal of Cardiology·Fabio GalettaFerdinando Pentimone
Nov 24, 2005·Asian Cardiovascular & Thoracic Annals·Shahzad G Raja, Gilles D Dreyfus
Jun 1, 1992·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·J D AndersonE E Moore
Sep 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·H R Freund, J Holroyde
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·José R FiorettoBeatriz B Matsubara
Mar 1, 1997·The American Journal of Physiology·M J TothE T Poehlman
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·M F Vandewoude, N Buyssens
Jun 1, 1987·Postgraduate Medicine·D S Moodie
May 17, 2000·Nutrition Reviews·M J Toth, E T Poehlman

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