Adverse life event reporting and worst illness episodes in unipolar and bipolar affective disorders: measuring environmental risk for genetic research

Psychological Medicine
Georgina M HosangAnne E Farmer

Abstract

Studies exploring gene-environment interplay in affective disorders now include very large numbers of participants. Methods for evaluating the role of adversity in such studies need to be developed that do not rely on lengthy and labour-intensive interviews. In the present study, a brief questionnaire method for measuring 11 adverse events reported before interview and before their worst illness episodes by bipolar, unipolar and healthy control participants, participating in genetic association studies, was evaluated. Five hundred and twelve bipolar disorder (BD) participants, 1447 participants with recurrent unipolar depression (UPD) and 1346 psychiatrically healthy control participants underwent the researcher-administered version of the List of Threatening Experiences Questionnaire (LTE-Q) for the 6 months before their worst affective episodes for UPD and BD participants, and for the 6 months before interview for the UPD participants and controls. UPD and BD cases were significantly more likely to report at least one event, as well as more events in the 6 months before interview and before their worst illness episodes, than healthy controls. Both manic and depressive episodes were significantly associated with adverse events...Continue Reading

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Citations

Aug 14, 2012·Journal of Affective Disorders·Judith ProudfootKristy Delmas
Oct 1, 2011·Depression Research and Treatment·Boaz Levy, Emily Manove
Nov 10, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Georgina M HosangAnne E Farmer
Feb 16, 2016·The Psychiatric Clinics of North America·Sheri L JohnsonAnda Gershon
Aug 8, 2012·Journal of Psychiatric Research·Georgina M HosangAnne E Farmer
Jul 17, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PowerRudolf Uher
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Aug 9, 2016·Psychiatry and Clinical Neurosciences·Fanny Aldinger, Thomas G Schulze
Oct 30, 2016·Journal of Affective Disorders·Claudia LexThomas D Meyer
Jan 20, 2017·Depression and Anxiety·Georgina M HosangAnne E Farmer
May 26, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Patrícia B de AbreuClarice S Madruga
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