Adverse mental health outcomes in a population-based cohort of survivors of childhood cancer

Cancer
Paul C NathanSumit Gupta

Abstract

The elevated risk for physical late effects in childhood cancer survivors (CCS) is well documented, but their risk for mental health problems is less well described. The authors assembled a cohort of all 5-year CCS who were diagnosed before age 18 years and treated in an Ontario pediatric cancer center between 1987 and 2008. Patients were matched to population controls and linked to health administration databases. The authors calculated rates of mental health care visits (family physician, psychiatrist, emergency department, hospitalization) and the risk for a severe mental health event (emergency department, hospitalization, suicide). Outcomes were compared using recurrent event and survival analyses. Compared with 20,269 controls, 4117 CCS had a higher rate of mental health visits (adjusted relative rate [RR], 1.34; 95% confidence interval [CI], 1.12-1.52). Higher rates were associated with female gender (RR, 1.39; CI, 1.10-1.75; P = .006) and being diagnosed at ages 15 to 17.9 years (compared with ages 0-4 years: RR, 1.81; 95% CI, 1.17-2.80; P = .008). Cancer type, treatment intensity, and treatments targeting the central nervous system were not significant predictors. Survivors were at increased risk for a severe event com...Continue Reading

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Citations

Feb 19, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Hannah L NewtonAdam W Glaser
Nov 19, 2019·Journal of Adolescent and Young Adult Oncology·Dara M SteinbergNicole M Schneider
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Aug 20, 2021·Journal of Cancer Survivorship : Research and Practice·Brenna E BlackburnNathalie Huguet
Jan 11, 2022·Journal for Specialists in Pediatric Nursing : JSPN·Megalai Thavakugathasalingam, Jasna K Schwind

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