Adverse Obstetric Outcomes Among Early-Onset Cancer Survivors in Finland

Obstetrics and Gynecology
Johanna MelinLaura Madanat-Harjuoja

Abstract

To evaluate risk of adverse obstetric outcomes and operative deliveries in female cancer survivors (diagnosed younger than 35 years of age) compared with female siblings of survivors. Nationwide cancer and birth registries were merged to identify 1,800 first postdiagnosis deliveries of female cancer survivors and 7,137 first deliveries of female siblings between January 1987 and December 2013. Multiple unconditional logistic regression models were used to estimate the risk for adverse obstetric outcomes and operative deliveries adjusting for maternal age, year of delivery, gestational age, and smoking. We found a significantly elevated risk for induction of labor, 19.1% in survivors and 15.6% in siblings (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.02-1.35) and cesarean delivery, 23.6% in survivors and 18.6% in siblings (OR 1.15, 95% CI 1.01-1.31) among cancer survivors compared with female siblings. The risks of instrumental vaginal delivery, malpresentation, placental pathologies, and postpartum hemorrhage were not, however, elevated among cancer survivors. The highest risks of adverse obstetric outcomes were seen among women treated in their childhood (aged 0-14 years). Cancer survivors have a small but statisticall...Continue Reading

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Citations

Aug 24, 2018·PloS One·Anne-Lotte L F van der KooiRichard A Anderson
Oct 24, 2018·International Journal of Cancer. Journal International Du Cancer·Johanna MelinLaura Madanat-Harjuoja
Jul 23, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Gabriela ArmuandGunilla Sydsjö
Mar 30, 2020·Journal of Cancer Research and Clinical Oncology·M van DijkM H van den Berg
Dec 22, 2019·Human Reproduction Update·Meaghan J GriffithsKarla J Hutt
Apr 19, 2017·Journal of the National Cancer Institute·Raoul C ReulenMike M Hawkins
May 7, 2021·Obstetrics and Gynecology·Roni NiteckiJ Alejandro Rauh-Hain

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