Adverse outcome pathway networks II: Network analytics

Environmental Toxicology and Chemistry
Daniel L VilleneuveDries Knapen

Abstract

Toxicological responses to stressors are more complex than the simple one-biological-perturbation to one-adverse-outcome model portrayed by individual adverse outcome pathways (AOPs). Consequently, the AOP framework was designed to facilitate de facto development of AOP networks that can aid in the understanding and prediction of pleiotropic and interactive effects more common to environmentally realistic, complex exposure scenarios. The present study introduces nascent concepts related to the qualitative analysis of AOP networks. First, graph theory-based approaches for identifying important topological features are illustrated using 2 example AOP networks derived from existing AOP descriptions. Second, considerations for identifying the most significant path(s) through an AOP network from either a biological or risk assessment perspective are described. Finally, approaches for identifying interactions among AOPs that may result in additive, synergistic, or antagonistic responses (or previously undefined emergent patterns of response) are introduced. Along with a companion article (part I), these concepts set the stage for the development of tools and case studies that will facilitate more rigorous analysis of AOP networks, an...Continue Reading

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Citations

Mar 1, 2018·Environmental Toxicology and Chemistry·Dries KnapenDaniel L Villeneuve
Feb 5, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nathan L PolleschJason M O'Brien
May 28, 2019·Environmental Toxicology and Chemistry·Markus Hecker, Carlie A LaLone
Mar 26, 2019·Integrated Environmental Assessment and Management·Katie CoadyTom Hutchinson
May 28, 2019·Environmental Toxicology and Chemistry·Edward J PerkinsStefan Scholz
May 14, 2020·International Journal of Radiation Biology·Vinita ChauhanDonald Cool
Apr 20, 2018·Environmental Health Perspectives·Michelle M AngrishBrian N Chorley
Jan 1, 2019·Environmental Sciences Europe·J B LegradiH Hollert
Aug 25, 2019·Archives of Toxicology·Nicoleta SpinuAndrew P Worth
May 20, 2020·Archives of Toxicology·Nicoleta SpinuAndrew P Worth
Dec 21, 2018·Environmental Toxicology and Chemistry·Daniel L VilleneuveNatàlia Garcia-Reyero
Sep 24, 2020·Integrated Environmental Assessment and Management·S Jannicke MoeKnut Erik Tollefsen
Dec 3, 2020·PLoS Computational Biology·Daniel Rivas-BarraganDaniel Domingo-Fernández
Dec 29, 2020·Environmental Health Perspectives·Paul WhaleyMichelle Angrish
Apr 23, 2020·Environmental Science & Technology·Evelyn StinckensDries Knapen
May 27, 2021·Environmental Science & Technology·Pu XiaXiaowei Zhang
May 23, 2021·Integrative and Comparative Biology·Paul BogdanNicholas Strausfeld
Jun 26, 2020·Environmental Science & Technology·Dries KnapenLucia Vergauwen
Jul 9, 2020·Chemical Research in Toxicology·Roman LiJulia Hoeng
Sep 1, 2021·Critical Reviews in Toxicology·Marlon R SchneiderRob J Vandebriel
Jul 31, 2019·Reproductive Toxicology·Thayne Woycinck KowalskiFernanda Sales Luiz Vianna
Sep 10, 2021·Environmental Toxicology and Chemistry·Dries Knapen
Oct 30, 2021·Environmental Toxicology and Chemistry·Stefan ScholzMartin von Bergen

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