Adverse outcomes of long-term use of proton pump inhibitors: a systematic review and meta-analysis

European Journal of Gastroenterology & Hepatology
Md Mohaimenul IslamYu-Chuan Jack Li

Abstract

The association between the long-term use of proton pump inhibitors (PPIs) and the risks of various diseases remains controversial. Therefore, the primary objective of this study was to quantify the associations as presented in the literature and to also provide this information to healthcare professionals and patients about their potentially adverse effects. In July 2016, we searched through Medline (PubMed), Embase, and the Cochrane Library from inception using common keywords. We included observational studies that provided risk estimates on the long-term use of PPIs and their adverse effects. Overall, 43 studies were included in the systematic review, of which 28 studies were also included in the random effect meta-analysis. Odds of community-acquired pneumonia, hip fracture, and colorectal cancer were 67% [odds ratio (OR)=1.67; 95% confidence interval (CI): 1.04-2.67], 42% (OR=1.42; 95% CI: 1.33-1.53), and 55% (OR=1.55; 95% CI: 0.88-2.73) higher in patients with long-term PPIs use compared with patients who did not use PPIs. Although the use of PPIs provides short-term health benefits, their prolonged use is associated with minor and also potentially major adverse health outcomes. Hence, we strongly recommend that the pres...Continue Reading

References

Sep 12, 1992·Lancet·F J GarroteJ Solís
Oct 19, 1991·Lancet·J P DutertreE Autret
Jan 1, 1987·Epidemiologic Reviews·S Greenland
Jan 1, 1994·Alimentary Pharmacology & Therapeutics·J M ShinG Sachs
Dec 17, 1994·BMJ : British Medical Journal·M BeutlerJ Gartmann
Feb 18, 1995·Lancet·A Kraus, L F Flores-Suárez
Dec 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·M ElisafK C Siamopoulos
Aug 1, 1996·Alimentary Pharmacology & Therapeutics·B E SchenkS G Meuwissen
Dec 22, 1999·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·J P Reilly
Dec 21, 2000·Journal of Clinical Pharmacy and Therapeutics·M NauntonM D Bleasel
Jul 27, 2001·Pharmacy World & Science : PWS·N M Walker, J McDonald
Apr 30, 2002·The Annals of Pharmacotherapy·J Mark RuscinRobert J Valuck
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 26, 2003·Alimentary Pharmacology & Therapeutics·F ParenteG Bianchi Porro
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jul 9, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sandra DialDick Menzies
Oct 28, 2004·JAMA : the Journal of the American Medical Association·Robert J F LaheijJan B M J Jansen
Feb 15, 2005·International Journal of Clinical Practice·A Z Mat SaadH J O'Connor
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Sandra DialSamy Suissa
Jul 20, 2006·The American Journal of Gastroenterology·Nicholas J ShaheenRobert S Sandler
Oct 27, 2006·Pharmacy World & Science : PWS·Kenneth GrantDavid Reith
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Yu-Xiao YangDavid C Metz
Aug 7, 2007·Gastroenterology·Douglas J RobertsonHenrik T Sørensen
Aug 7, 2007·Gastroenterology·Yu-Xiao YangJames D Lewis
Dec 12, 2007·The American Journal of Gastroenterology·Eva M van SoestErnst J Kuipers
Jan 5, 2008·BMJ : British Medical Journal·Ian Forgacs, Aathavan Loganayagam
Jan 25, 2008·The European Respiratory Journal·J AlmirallUNKNOWN Community-Acquired Pneumonia in Catalan Countries (PACAP) Study Group
Jul 19, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hani TamimJacques Lelorier
Sep 16, 2008·Gastroenterology·Peter J KahrilasUNKNOWN American Gastroenterological Association
Sep 17, 2008·Annals of Internal Medicine·Monika SarkarYu-Xiao Yang
Sep 25, 2008·Calcified Tissue International·Elaine W YuDouglas C Bauer
Oct 3, 2009·Epidemiology·Luis Alberto García RodríguezSaga Johansson
Jan 6, 2010·Alimentary Pharmacology & Therapeutics·R TurcoA Staiano
Mar 17, 2010·Annals of Internal Medicine·Wayne A RayC Michael Stein
May 12, 2010·Journal of Clinical Pharmacy and Therapeutics·M K FallahzadehM R Namazi
May 12, 2010·Archives of Internal Medicine·Amy LinskyJohn A Hermos

❮ Previous
Next ❯

Citations

Nov 22, 2018·European Journal of Gastroenterology & Hepatology·Md Mohaimenul IslamYu-Chuan Jack Li
Nov 22, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Amandeep SinghGail A Cresci
Nov 22, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Katsuhiro Toda
Jan 19, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A SonnenbergR M Genta
Dec 8, 2019·Journal of Gastroenterology·Nele BrusselaersLars Engstrand
Sep 29, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Benjamin Lazarus, Morgan E Grams
Dec 18, 2019·BMJ Quality & Safety·Christine Soong, Kaveh G Shojania
Jun 27, 2019·World Journal of Gastroenterology : WJG·Giovanni BrunoCarola Severi
Jun 18, 2020·European Journal of Clinical Pharmacology·Hyun Jin SongPatrick Squires
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Su XuMinggui Wang
Dec 13, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T N PolyY-C J Li
Jul 3, 2020·The Journal of Dermatology·Ying-Xiu DaiMu-Hong Chen
Dec 24, 2018·European Journal of Gastroenterology & Hepatology·Shih-Wei LaiKuan-Fu Liao
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Michael Wakeman, David T Archer
Sep 5, 2020·Alimentary Pharmacology & Therapeutics·Cheng Mei Li, Nele Brusselaers
Nov 25, 2020·BMJ : British Medical Journal·David A Katzka, Peter J Kahrilas
Dec 29, 2020·British Journal of Clinical Pharmacology·Sophie LiabeufUNKNOWN Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD REIN) Study Group
Jan 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li YangShiming Yang
Feb 3, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Luca Schiliró TristãoWanderley Marques Bernardo
Oct 23, 2020·International Journal of Clinical Oncology·Hyun Jin SongIn-Hyuk Ha
Mar 3, 2021·Surgical Endoscopy·Sophia K McKinleyBethany J Slater
Mar 19, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Yasutoshi ShiratoriRyota Niikura
Jun 12, 2021·Alimentary Pharmacology & Therapeutics·Elizabeth M SalvoPeter J Kahrilas
Mar 27, 2021·Minerva Urology and Nephrology·Carolina S VengrusPaulo R Bignardi
Nov 23, 2021·The American Journal of Gastroenterology·Philip O KatzStuart Jon Spechler

❮ Previous
Next ❯

Software Mentioned

Review Manager

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Translational Medicine
K WijarnpreechaPatompong Ungprasert
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
A Tran-DuyC D A Stehouwer
© 2022 Meta ULC. All rights reserved