PMID: 7542379Aug 1, 1995Paper

Adverse pregnancy outcome after a false-positive screen for Down syndrome using multiple markers

Obstetrics and Gynecology
Eugene PergamentM J Kupferminc

Abstract

To assess the relative risk of an adverse pregnancy outcome in women whose multiple-marker screening (maternal serum alpha-fetoprotein [MSAFP], unconjugated estriol [E3], and hCG levels, and age) indicating an increased risk for Down syndrome (more than 1:250) was not confirmed by amniocentesis. Fifty-eight women with false-positive screens for Down syndrome were matched with a control group of 116 women whose screens indicated a risk for Down syndrome of less than 1:250. The risk for adverse pregnancy outcome was compared for the two groups, and the roles of MSAFP, unconjugated E3, and hCG as predictors of adverse pregnancy outcome were determined. Women with false-positive screens for Down syndrome were significantly different from their matched controls in the incidence of preterm delivery (20.6 versus 8.6%, respectively), preeclampsia (6.9 versus 0%), small for gestational age newborns (5.2 versus 0%), and fetal demise after 20 weeks' gestation (5.2 versus 0%). An adverse outcome occurred in 19 of 58 pregnancies (32.8%) in the study group and in 14 of 116 matched control pregnancies (12%) (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.6-7.8; P < .01). Unconjugated E3 of 0.75 multiples of the mean (MoM) or less was sig...Continue Reading

Citations

Sep 12, 2002·Prenatal Diagnosis·Yuval YaronAvi Orr-Urtreger
Nov 13, 2004·Fetal Diagnosis and Therapy·Bojana Brajenović-MilićMiljenko Kapović
Jan 22, 2011·Fetal Diagnosis and Therapy·Park Hea ReeJi Young Huh
Jul 28, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·L M YeeK Bianco
Jun 28, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A J AntsaklisS S Michalas
Jul 24, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter A Benn
Nov 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G CentiniF Petraglia
Sep 23, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·A Conde-AgudeloA T Papageorghiou
May 1, 2009·Environmental Toxicology and Pharmacology·Anuradha David, Katti Pancharatna
Jul 1, 2009·Journal of Medical Screening·Michael R LaoChristos G Hatjis
Nov 6, 2007·Obstetrics and Gynecology·Uma M Reddy
Jan 8, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T A YaryginaF Figueras

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