Abstract
This study assessed prevalence of connective tissue disease (CTDs), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and antiphospholipid antibodies (aPL) in women with previous adverse pregnancy outcome compared with uncomplicated livebirths. Retrospective case-control study. UK Primary Care. Records of women, 18 years and older, within the Clinical Practice Research Datalink (CPRD) (1 January 2000-31 December 2013). Clinical Practice Research Datalink was searched for pregnancy terms to identify adverse pregnancy outcome. Each identified case was matched to five livebirths. Diagnosis of SLE, CTD, APS or autoimmune antibodies. Poisson regression was performed to calculate relative risk ratios (RR), comparing adverse pregnancy outcome with livebirth cohorts. Clinical Practice Research Datalink identified 20 123 adverse pregnancy outcomes matched to 97 323 livebirths, with a total of 875 590 person-years follow up. Median follow up from study entry was 7.29 years (SD 4.39). Compared with women with an uncomplicated livebirth, women with adverse pregnancy outcome had an increased risk of developing CTD or autoimmune antibodies (RR 3.20, 95% CI 2.90-3.51). Risk was greatest following a stillbirth (RR 5.82, 95% ...Continue Reading
References
Jul 1, 1987·Archives of Disease in Childhood·P B TerryD F Kerridge
Apr 1, 1995·Arthritis and Rheumatism·A E JohnsonP A Bacon
Apr 17, 2001·American Journal of Obstetrics and Gynecology·F LackmanR Gagnon
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·Janet R HardyMichael B Bracken
Oct 6, 2005·American Journal of Obstetrics and Gynecology·J Patricia DharRobert J Sokol
May 16, 2006·Pharmacoepidemiology and Drug Safety·A L NightingaleC S de Vries
May 2, 2007·Arthritis and Rheumatism·Emily C SomersAndrew J Hall
Oct 22, 2008·Journal of Epidemiology and Community Health·S Fredsted VilladsenA M Nybo Andersen
Nov 15, 2008·Japanese Journal of Clinical Oncology·Koji MatsumotoMichihide Mitsumori
Nov 28, 2008·Obstetrics and Gynecology·Anna Maria MarconiFrederick C Battaglia
Jul 2, 2009·The Journal of Rheumatology·Constance J Ulff-MøllerMorten Frisch
Aug 7, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Andrew SmythVesna D Garovic
Sep 25, 2010·Autoimmunity Reviews·Marta MoscaStefano Bombardieri
Oct 18, 2011·Autoimmunity Reviews·Claudio Galarza-MaldonadoNikolai F Soroka
Jan 10, 2012·Journal of Autoimmunity·Kristian Tore JørgensenMorten Frisch
Feb 14, 2012·Paediatric and Perinatal Epidemiology·Ruth CockerillAlexander E P Heazell
Aug 8, 2013·PloS One·Alyshah Abdul SultanJoe West
Aug 15, 2013·Lupus·V GolderA Hoi
Oct 8, 2013·Lupus·L A GonzálezG S Alarcón
Feb 8, 2014·Arthritis & Rheumatology·Emily C SomersW Joseph McCune
May 14, 2014·Autoimmunity Reviews·Silvia D'IppolitoNicoletta Di Simone
Jun 7, 2014·American Journal of Obstetrics and Gynecology·Roy KessousEyal Sheiner
Jul 16, 2014·Annals of Family Medicine·Donna R ParkerCharles B Eaton
Jul 30, 2014·American Journal of Obstetrics and Gynecology·Gali ParienteEyal Sheiner
Apr 1, 2012·Therapeutic Advances in Drug Safety·Tim WilliamsSusan Eaton
Oct 1, 2014·Annals of the Rheumatic Diseases·Frances ReesWeiya Zhang
Jun 26, 2015·BMJ : British Medical Journal·Kathleen LamontSohinee Bhattacharya
Mar 1, 2017·Lupus Science & Medicine·Alison L NightingaleNeil J McHugh