PMID: 7008734Feb 23, 1981Paper

Adverse reactions of aspirin and related drugs

Archives of Internal Medicine
G A Settipane

Abstract

The term "aspirin intolerance" is defined as acute urticaria-angioedema, bronchospasm, severe rhinitis, or shock occurring within three hours of aspirin ingestion. Aspirin intolerance occurs most commonly in patients with chronic urticaria (23%), in whom it is mostly manifested by the urticaria type of aspirin tolerance, and in asthmatic individuals (4%), in whom it is mostly manifested by the bronchospastic type. There is no definite evidence that aspirin intolerance is mediated by an immunologic reaction. In the bronchospastic type, an association between prostaglandins and the slow-reacting substance of anaphylaxis (SRS-A) seems likely. It is possible that aspirin causes a preponderance of prostaglandin F2 alpha (PGF2 alpha), resulting in bronchospasm. The effect of aspirin on blood histamine is controversial. The two major types of aspirin intolerance seem to be mediated by different mechanisms.

Citations

Aug 1, 1997·Archives of Pharmacal Research·S J LeeJ S Ahn
Sep 29, 2001·Anaesthesia·R D MacPherson
Jan 1, 1990·European Journal of Clinical Pharmacology·L Van Diem, J P Grilliat
May 12, 2009·Prostaglandins & Other Lipid Mediators·Joseph H Butterfield
Nov 1, 1985·Seminars in Arthritis and Rheumatism·C L Malmsten
Apr 1, 1984·Allergy·M L KowalskiM Szmidt
Jul 8, 2009·Current Medical Research and Opinion·Glenis Scadding
Jan 1, 1984·Scandinavian Journal of Rheumatology. Supplement·C Malmsten
Dec 1, 1991·AORN Journal·V A Goins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.