Adverse reactions to first-line antituberculosis drugs

Expert Opinion on Drug Safety
Eric J Forget, Dick Menzies

Abstract

Tuberculosis continues to be a major cause of morbidity and mortality worldwide. Currently available drugs are effective for treatment of the disease or latent infection, but may cause serious adverse effects. The authors reviewed the literature for side effects of five first-line antituberculous medications (isoniazid, rifampin, pyrazinamide, ethambutol and streptomycin). Incidence of the major side effects were compiled with particular attention to the incidence of isoniazid hepatotoxicity. Hepatotoxicity to isoniazid is a serious problem. Although overall incidence may be decreasing, incidence averaged 9.2 per 1000 patients who were compliant, in multiple studies, with a case fatality rate of 4.7%. The incidence is higher with increasing age. Other serious adverse effects include dermatological, gastrointestinal, hypersensitivity, neurological, haematological and renal reactions. They can lead to drug discontinuation (in up to 10% of patients) or even more serious morbidity or mortality. Side effects to antituberculosis drugs are common, and include hepatitis, cutaneous reactions, gastrointestinal intolerance, haematological reactions and renal failure. These adverse effects must be recognised early, to reduce associated mor...Continue Reading

References

May 1, 1978·Annals of Internal Medicine·N F RothfieldJ W Garfield
Mar 1, 1977·The Journal of Antimicrobial Chemotherapy·D J Girling
Jan 1, 1979·Archives of Disease in Childhood·P SpyridisC Papadatos
Feb 1, 1979·Chest·J F DastaS Kurzrok
Dec 1, 1979·International Journal of Epidemiology·G R HoweA B Miller
Oct 21, 1978·British Medical Journal·N SenanayakeS Kanagasuriyam
Oct 17, 1977·JAMA : the Journal of the American Medical Association·N F Jacobs, S E Thompson
Apr 1, 1978·Annals of Internal Medicine·C K Smith, D T Durack
Feb 1, 1976·Annals of Internal Medicine·J R MitchellS D Nelson
Mar 1, 1977·The Journal of the Indiana State Medical Association·J T Deppe
Jul 1, 1975·Clinical Pharmacology and Therapeutics·J R MitchellH R Keiser
Jan 24, 1976·British Medical Journal·F E Cayley, S K Majumdar
Mar 1, 1976·Southern Medical Journal·J R Coyer, D P Nicholson
Feb 11, 1992·The American Review of Respiratory Disease·D E Snider, G J Caras
Dec 1, 1991·The American Review of Respiratory Disease·T J JordanL B Reichman
Feb 1, 1991·Chest·M A SteeleR M DesPrez
Mar 1, 1991·The American Journal of Medicine·H S Schild, B C Fox
May 1, 1990·The American Review of Respiratory Disease·A K DuttW W Stead
Nov 15, 1990·Annals of Internal Medicine·R MurphyP B Watkins
Jun 1, 1985·International Journal of Dermatology·M R Holdiness
Sep 1, 1989·The American Review of Respiratory Disease·T S MouldingG C Kanel
Sep 21, 1985·Lancet·M ToutoungiL Perey
Apr 1, 1989·The American Review of Respiratory Disease·A K DuttW W Stead
Mar 29, 1986·British Medical Journal·M GullifordK Prowse
Apr 1, 1985·The British Journal of Dermatology·R YamasakiR Nagasako
Jan 1, 1988·The American Review of Respiratory Disease·J TsevatS G Pauker
Oct 1, 1987·The Journal of Allergy and Clinical Immunology·S AsaiK Fujiwara
Dec 1, 1987·Annals of Internal Medicine·W W SteadJ H Abraham
Mar 1, 1987·The American Journal of Emergency Medicine·D G HankinsB J Warren
Apr 1, 1987·Chest·N Y Gabrail
Jul 1, 1972·Chest·A L Goldman, S S Braman
Jul 1, 1973·Annals of Internal Medicine·W C Maddrey, J K Boitnott

❮ Previous
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Citations

Oct 14, 2010·European Journal of Clinical Pharmacology·Sang-Heon KimYoung Koo Jee
May 3, 2007·Wiener medizinische Wochenschrift·Sascha MeyerMarkus Klotz
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kashef IjazKenneth G Castro
Mar 30, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Damon P Eisen, Justin S Denholm
Jul 3, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara J SeaworthDavid E Griffith
May 19, 2011·The Journal of Antimicrobial Chemotherapy·Raúl J Andrade, Paul M Tulkens
Oct 2, 2012·Journal of Gastroenterology and Hepatology·Harshad DevarbhaviGirisha Balaraju
May 26, 2006·Antimicrobial Agents and Chemotherapy·Iftach YacobyItai Benhar
Apr 26, 2007·Annals of the Rheumatic Diseases·Jérémie SellamUNKNOWN RATIO (Research Axed on Tolerance of Biotherapies) Study Group
May 23, 2012·Advances in Pharmacological Sciences·Etienne MokondjimobeHenri-Joseph Parra
Dec 21, 2011·The European Respiratory Journal·Marieke J van der WerfDavide Manissero
Feb 20, 2009·Health and Quality of Life Outcomes·Na GuoCarlo A Marra
Jul 21, 2011·Journal of Medical Case Reports·Abdulkabir A Ayanniyi, Rashidat O Ayanniyi
Mar 22, 2013·Journal of Ophthalmic Inflammation and Infection·Sharel OngchinGurunadh Atma Vemulakonda
Feb 4, 2012·The American Journal of Tropical Medicine and Hygiene·Thomas C HaveyWayne L Gold
Nov 5, 2011·Asia Pacific Allergy·Bernard Yu-Hor Thong
Mar 11, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A GauchonJ-L Bernard
Jun 19, 2007·Médecine et maladies infectieuses·P Tattevin
Jan 29, 2010·Infection·J M LeitnerF Thalhammer
Oct 17, 2009·Ocular Immunology and Inflammation·Daniel V Vasconcelos-SantosNarsing A Rao
Apr 20, 2012·Expert Review of Anti-infective Therapy·Rannakoe J Lehloenya, Keertan Dheda
May 21, 2011·Expert Review of Clinical Immunology·Eva Salgado, Juan J Gómez-Reino
Jun 29, 2010·Enfermedades infecciosas y microbiología clínica·Vicente GinerMaría José Esteban
May 16, 2009·Clinics in Liver Disease·Christopher B O'Brien
Aug 29, 2007·Clinics in Liver Disease·Julie E Polson
Feb 13, 2007·Bioorganic & Medicinal Chemistry·Yves L Janin
Nov 22, 2011·Hemodialysis International·Bakshish Singh, Gurpreet Singh
Aug 19, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Jakob P CramerStefan Kluge
Mar 11, 2015·International Journal of Dermatology·Tulin ErgunSait Karakurt
Oct 27, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Francisco Jose ForestieroRosario Dominguez Crespo Hirata
Jun 16, 2015·Trends in Pharmacological Sciences·Geetha Vani Rayasam, Tanjore S Balganesh
Jul 24, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mark H KuniholmKenrad E Nelson
Jun 29, 2013·Environmental Toxicology and Pharmacology·Riffat FatimaKhaleeq Anwar
Sep 23, 2014·Regulatory Toxicology and Pharmacology : RTP·Christine M HuntAyako Suzuki
Apr 2, 2010·Allergy, Asthma & Immunology Research·Bernard Yu-Hor Thong
Nov 22, 2011·The Korean Journal of Hepatology·Ju Seung KimJu Hyun Kim
Nov 2, 2013·The World Allergy Organization Journal·Mario Sánchez-BorgesMaria José Torres Jaén
Jul 6, 2016·Ocular Immunology and Inflammation·Marcus AngSoon-Phaik Chee
May 28, 2016·Pharmacogenetics and Genomics·Daniel J KleinTeri E Klein
Aug 20, 2016·Genetic Testing and Molecular Biomarkers·Soukaina GuaouaAbdelaziz Sefiani
Aug 7, 2014·Asia Pacific Allergy·Bernard Yu-Hor ThongHiok-Hee Chng
Feb 15, 2014·Asia Pacific Allergy·Evy YunihastutiTeguh Harjono Karjadi
Nov 7, 2016·The British Journal of Ophthalmology·Marcus Ang, Soon-Phaik Chee

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