PMID: 590302Nov 14, 1977

Adverse reactions to practolol in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program

European Journal of Clinical Pharmacology
H J PfeiferJ Koch-Weser

Abstract

Adverse reactions to practolol were studied in 198 prospectively monitored hospitalized medical patients. The mean age of the practolol recipients was 57 years; angina and cardiac arrhythmias were the most common indications for therapy. Adverse reactions were attributed to practolol in 20 patients (10%). Fifteen of these twenty reactions involved impairment of cardiac function (bradyarrhythmias, heart block, congestive heart failure, hypotension), and in three instances the reaction was considered life-threatening. Three additional patients had cutaneous reactions attributed to the drug. Adverse reactions to practolol were not dose-related, but toxicity appeared to be more frequent among patients concurrently receiving quinidine. The frequency of cardiovascular complications of propranolol in a similar series of patients was nearly identical. However, no skin reactions were attributed to propranolol. The findings suggest that practolol and propranolol produce unwanted cardiovascular effects with nearly equal frequency among hospitalized patients. Cutaneous reactions to practolol are evident even during short-term use.

References

Jan 1, 1975·Drugs·H J Wall-Manning
Jan 1, 1976·Acta Medica Scandinavica·H A JensenJ Sondergaard
Mar 1, 1973·Circulation·R E Goldstein
May 26, 1973·British Medical Journal·E B Raftery, A M Denman
Nov 9, 1974·British Medical Journal·R H FelixM G Dahl
Oct 17, 1974·The New England Journal of Medicine·H Jick

Citations

Dec 13, 2006·Social History of Medicine : the Journal of the Society for the Social History of Medicine·John Abraham, Courtney Davis
Jul 1, 1979·British Journal of Clinical Pharmacology·D H Lawson

Related Concepts

Cardiovascular Diseases
Digitalis Glycosides
Drug Interactions
Dalzic
Quinidex

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