Adverse side effects of dexamethasone in surgical patients

The Cochrane Database of Systematic Reviews
Jorinde Aw PoldermanJeroen Hermanides

Abstract

In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However, whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied. To assess the effects of a steroid load of dexamethasone on postoperative systemic or wound infection, delayed wound healing, and blood glucose change in adult surgical patients (with planned subgroup analysis of patients with and without diabetes). We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), in the Cochrane Library, and the Web of Science for relevant articles on 29 January 2018. We searched without language or date restriction two clinical trial registries to identify ongoing studies, and we handsearched the reference lists of relevant publications to identify all eligible trials. We searched for randomized controlled trials comparing an i...Continue Reading

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Citations

Nov 28, 2018·The Cochrane Database of Systematic Reviews·Jorinde Aw PoldermanJeroen Hermanides
Mar 30, 2019·The Cochrane Database of Systematic Reviews·James K JewerRonald B George
Jul 25, 2019·The Cochrane Database of Systematic Reviews·Sharon R LewisAndrew F Smith
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