Abstract
Patients with aplastic anaemia or myelodysplastic syndromes frequently receive transfusions in an attempt to correct anaemia and/or thrombocytopenia, putting them at risk of adverse transfusion reactions. The aim of this study is to evaluate the incidence and the types of adverse transfusion reactions in these patients. Adverse transfusion reaction reported in transfused patients with aplastic anaemia or myelodysplastic syndromes from all the hospitals in the Auvergne-Rhône-Alpes region of France were extracted from the national haemovigilance database system and analysed. The types of adverse transfusion reactions, their incidence, their severity, the blood component involved and its imputability were evaluated. From 1 January 2010 to 30 June 2016, 7174 adverse transfusion reactions were reported. Seventy adverse transfusion reactions (0·9%) were reported in patients with aplastic anaemia and 193 (2·7%) in patients with myelodysplastic syndromes. Febrile non-haemolytic transfusion reaction was the most common reaction both aplastic anaemia (23 cases, 33·0%) and myelodysplastic syndrome (56 cases, 29·0%). Post-transfusion red blood cell alloimmunization was also high in both these groups (17·1% in patients with aplastic anaemia...Continue Reading
References
May 8, 1997·The New England Journal of Medicine·N S Young, J Maciejewski
Jun 17, 2006·Blood·Neal S YoungPhillip Scheinberg
Mar 7, 2008·Haematologica·Eva MontanéUNKNOWN Catalan Group for Study of Agranulocytosis and Aplastic Anemia
Feb 12, 2009·Vox Sanguinis·UNKNOWN ISBT Working Party on Granulocyte ImmunobiologyB Zupanska
Nov 6, 2009·The New England Journal of Medicine·Ayalew Tefferi, James W Vardiman
Oct 30, 2010·Vox Sanguinis·J KitazawaH Ohto
Dec 14, 2011·Hematology·Manuel G AfableJaroslaw P Maciejewski
Jun 29, 2012·The American Journal of Medicine·Xiaomei Ma
Aug 1, 2012·Transfusion·Cristina SanzArturo Pereira
Aug 12, 2014·Haematologica·Sung-Yong KimH Joachim Deeg
Oct 7, 2014·British Journal of Haematology·Joan CidUNKNOWN Biomedical Excellence for Safer Transfusion collaborative
Dec 4, 2014·Vox Sanguinis·M MenisH S Izurieta
Feb 17, 2015·Clinical and Experimental Immunology·Y Zeng, E Katsanis
Dec 23, 2015·Vox Sanguinis·M A M RogersN Blumberg
Jan 12, 2016·Transfusion Medicine·F BaíaF Araújo
Apr 14, 2016·Blood·Daniel A ArberJames W Vardiman
Sep 23, 2016·Vox Sanguinis·C PolitisE M Wood
Dec 4, 2016·Hematology·Akiko Shimamura
Jan 18, 2017·Blood·Andrea Bacigalupo
Jan 18, 2017·Vox Sanguinis·Y LinR Buckstein
Oct 7, 2017·Haematologica·Deepak SinghalDevendra K Hiwase
Apr 21, 2018·British Journal of Haematology·Matthew S KarafinUNKNOWN NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)
Jun 22, 2018·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Johanna ReckhausBehrouz Mansouri Taleghani
Citations
Mar 8, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·O Garraud
Jun 6, 2021·Blood Reviews·Esther N OlivaMikkael A Sekeres
Jun 24, 2021·Zeitschrift für Gerontologie und Geriatrie·Lin Zhu, Sandra Schütze