Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects

The British Journal of Psychiatry : the Journal of Mental Science
C MorganStephani L Hatch

Abstract

There is robust evidence that childhood adversity is associated with an increased risk of psychosis. There is, however, little research on intervening factors that might increase or decrease risk following childhood adversity. To investigate main effects of, and synergy between, childhood abuse and life events and cannabis use on odds of psychotic experiences. Data on psychotic experiences and childhood abuse, life events and cannabis use were collected from 1680 individuals as part of the South East London Community Health Study (SELCoH), a population-based household survey. There was strong evidence that childhood abuse and number of life events combined synergistically to increase odds of psychotic experiences beyond the effects of each individually. There was similar, but weaker, evidence for cannabis use (past year). Our findings are consistent with the hypothesis that childhood abuse creates an enduring vulnerability to psychosis that is realised in the event of exposure to further stressors and risk factors.

References

Oct 1, 1980·American Journal of Epidemiology·K J RothmanA M Walker
Oct 28, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Stephani L Hatch
Aug 30, 2007·International Journal of Epidemiology·Mirjam J KnolMirjam I Geerlings
Aug 16, 2008·Schizophrenia Bulletin·Richard P Bentall, Charles Fernyhough
Apr 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Helen FisherPaul Fearon
Jun 2, 2010·Schizophrenia Bulletin·Craig MorganRobin M Murray
Sep 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Kenneth S Kendler, Charles O Gardner
Sep 17, 2010·American Journal of Epidemiology·Ann Kristin KnudsenArnstein Mykletun
Apr 22, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Paul BebbingtonRachel Jenkins
Jul 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Scott WeichSarah Stewart-Brown
Jul 13, 2011·Schizophrenia Research·Rebecca KuepperJim van Os
Jul 28, 2012·Schizophrenia Bulletin·Ezra Susser, Cathy S Widom
Jul 31, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Jayati Das-MunshiMartin J Prince
Oct 12, 2012·Social Psychiatry and Psychiatric Epidemiology·Jamie MurphyGary Adamson
Jan 12, 2013·Social Psychiatry and Psychiatric Epidemiology·Katherine G Jonas, Kristian E Markon
Apr 24, 2013·Social Psychiatry and Psychiatric Epidemiology·Souci FrissaMatthew Hotopf
May 15, 2013·Schizophrenia Bulletin·Stephanie BeardsCraig Morgan

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Citations

Feb 18, 2016·Schizophrenia Research·Clare OakleyMarco Picchioni
Feb 3, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Emmanuelle PetersPhilippa A Garety
Oct 2, 2015·Journal of Psychiatric Research·María Luisa BarrigónMiguel Ruiz-Veguilla
Jun 23, 2015·BJPsych Open·Antonella TrottaHelen L Fisher
Jul 15, 2015·Epidemiology and Psychiatric Sciences·E LongdenJ Read
Apr 22, 2015·Journal of Psychiatric Research·E Rubio-AbadalJ Usall
May 23, 2016·Schizophrenia Research·G BaudinUNKNOWN FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Collaborators
Jun 7, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Craig Morgan, Charlotte Gayer-Anderson
Jun 7, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Jim van Os, Uli Reininghaus
Feb 26, 2016·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Eleanor LongdenMitch G Waterman
Aug 16, 2016·Psychological Medicine·P SchofieldS L Hatch
Jul 1, 2017·Addiction·Hans Oh, Jordan DeVylder
Dec 14, 2017·The Australian and New Zealand Journal of Psychiatry·Baptiste PignonAli Amad
Aug 15, 2017·Early Intervention in Psychiatry·Vishal BhavsarPaolo Fusar-Poli
Sep 11, 2018·Epidemiology and Psychiatric Sciences·V BhavsarM Hotopf
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Craig MorganGerard Hutchinson
Feb 13, 2020·Schizophrenia Bulletin·Stephanie BeardsCraig Morgan
Jul 4, 2020·The Journal of Nervous and Mental Disease·Baptiste PignonPierre A Geoffroy
Jun 7, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Alison R Yung, Ashleigh Lin
Sep 2, 2017·Social Psychiatry and Psychiatric Epidemiology·Steven HoningsJim van Os
Sep 18, 2018·European Journal of Psychotraumatology·Sarah CarrMiriam Fornells-Ambrojo
Dec 29, 2017·Early Intervention in Psychiatry·Amy E LansingAudrey N Beck
Oct 11, 2017·Epidemiology and Psychiatric Sciences·V BhavsarC Morgan
Nov 27, 2019·Journal of Clinical Medicine·Pedro Bendala-RodríguezJuan F Rodríguez-Testal
Oct 25, 2020·Social Psychiatry and Psychiatric Epidemiology·Ioannis BakolisIan S Mudway
Dec 16, 2020·NPJ Schizophrenia·Linda T BetzUNKNOWN PRONIA consortium
Feb 9, 2021·The International Journal of Social Psychiatry·Hans OhAi Koyanagi
May 11, 2021·Social Psychiatry and Psychiatric Epidemiology·Emma YappSiân Oram
Jun 4, 2021·Psychological Medicine·Ian Kelleher, Mary Cannon

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