Adversity in childhood and depression: linked through SIRT1

Translational Psychiatry
L Lo IaconoV Carola

Abstract

Experiencing an adverse childhood and parental neglect is a risk factor for depression in the adult population. Patients with a history of traumatic childhood develop a subtype of depression that is characterized by earlier onset, poor treatment response and more severe symptoms. The long-lasting molecular mechanisms that are engaged during early traumatic events and determine the risk for depression are poorly understood. In this study, we altered adult depression-like behavior in mice by applying juvenile isolation stress. We found that this behavioral phenotype was associated with a reduction in the levels of the deacetylase sirtuin1 (SIRT1) in the brain and in peripheral blood mononuclear cells. Notably, peripheral blood mRNA expression of SIRT1 predicted the extent of behavioral despair only when depression-like behavior was induced by juvenile--but not adult--stress, implicating SIRT1 in the regulation of adult behavior at early ages. Consistent with this hypothesis, pharmacological modulation of SIRT1 during juvenile age altered the depression-like behavior in naive mice. We also performed a pilot study in humans, in which the blood levels of SIRT1 correlated significantly with the severity of symptoms in major depressio...Continue Reading

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Citations

Jan 22, 2019·Frontiers in Genetics·Lyubomir I AftanasSergei P Kovalenko
Jun 6, 2020·Nature Communications·Timothy M RobinetteSergiy Libert
Oct 6, 2017·The Journal of Comparative Neurology·E A B Gilbert, M K Vickaryous
Nov 21, 2017·Psychiatry and Clinical Neurosciences·Shusaku UchidaYoshifumi Watanabe
Jan 15, 2021·Neurochemistry International·Hitomi MatsunoKazuhiro Sohya

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Methods Mentioned

BETA
blood collection
PCR
transgenic
confocal microscopy

Software Mentioned

Statistica
SDS
EthoVision
ImageJ

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