Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease

Nutrition Research
Sera KimHyun-Sook Kim

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a simple steatosis, in which fat accumulates more than 5% in the liver, and regarded as most common liver diseases worldwide. Because NAFLD can be developed to severe liver disease and correlated with metabolic disease, its importance is currently emphasized. Occurrence of NAFLD is strongly related to dietary patterns and lifestyles; therefore, the suggestion of physiologically beneficial food is essential. Based on these, adzuki beans containing anthocyanin, catechin, and adzukisaponin are suggested as a health-beneficial food. Moreover, the effects of adzuki beans on metabolic improvement are not well established through the in vivo studies. Therefore, this study hypothesized that adzuki beans can alleviate lipid accumulation and oxidative stress-mediated inflammation in high-cholesterol and high-fat diet-induced NALFD mice. To demonstrate its effects, 6-week-old C57BL/6 male mice were allocated into 4 groups and fed a normal diet (ND), a high-cholesterol and high-fat diet (HCD), and HCD with 10% and 20% adzuki bean for 10 weeks. The result shows that fasting blood glucose, serum and hepatic triglyceride and cholesterol levels, and antioxidative enzyme activity ameliorated in the ad...Continue Reading

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Citations

May 16, 2018·The British Journal of Nutrition·Xuejuan XiaJianquan Kan
Jan 20, 2018·Food & Function·Nashwa Ahmed El-ShinnawyGamal Badr
Jun 21, 2019·Food & Function·Bárbara Pereira da SilvaHércia Stampini Duarte Martino
Jul 25, 2019·Food & Function·Renata Celi Lopes ToledoJosé Humberto de Queiroz
Feb 24, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Alireza BahramiAzita Hekmatdoost
Feb 6, 2019·Food Research International·Bárbara Pereira da SilvaHércia Stampini Duarte Martino

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