Adzuki bean (Vigna angularis ) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease

Nutrition Research and Practice
Honami MiyazakiShinichi Yonekura

Abstract

Alzheimer's disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein (Aβ) in the brain may be closely correlated with the development of Alzheimer's disease. In this study, the effects of an adzuki bean extract on the aggregation of Aβ were examined; moreover, the anti-Alzheimer's activity of the adzuki extract was examined. First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on Aβ42 aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer's disease in vivo, Aβ42-overexpressing Drosophila were used. In these flies, overexpression of Aβ42 induced the formation of Aβ42 aggregates in the brain, decreased motor function, and resulted in cognitive impairment. Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of Aβ42 aggregates in a concentration-dependent manner. When Aβ42-overexpressing flies were fed regular medium containing adzuki extract, the Aβ42 level in the brain was significantly lower than that in ...Continue Reading

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Citations

Aug 29, 2020·Journal of Food Science·Fu YangEric Marchioni
May 15, 2021·Critical Reviews in Food Science and Nutrition·Sorayya Kheirouri, Mohammad Alizadeh

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Methods Mentioned

BETA
transgenic
transmission electron microscopy
ELISA

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

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