Aedes aegypti salivary gland extract ameliorates experimental inflammatory bowel disease

International Immunopharmacology
Helioswilton Sales-CamposCristina Ribeiro de Barros Cardoso

Abstract

Current therapies for inflammatory bowel disease (IBD) are not totally effective, resulting in persistent and recurrent disease for many patients. Mosquito saliva contains immunomodulatory molecules and therein could represent a novel therapy for IBD. Here, we demonstrated the therapeutic activity of salivary gland extract (SGE) of Aedes aegypti on dextran sulfate sodium (DSS)-induced colitis. For this purpose, C57BL/6 male mice were exposed to 3% DSS in drinking water and treated with SGE at early (days 3-5) or late (days 5-8) time points, followed by euthanasia on days 6 and 9, respectively, for sample collection. The results showed an improvement in clinical disease outcome and postmortem scores after SGE treatment, accompanied by the systemic reduction in peripheral blood lymphocytes, with no impact on bone marrow and mesenteric lymph nodes cellularity or macrophages toxicity. Moreover, a local diminishment of IFN-γ, TNF-α, IL-1β and IL-5 cytokines together with a reduction in the inflammatory area were observed in the colon of SGE-treated mice. Strikingly, early treatment with SGE led to mice protection from a late DSS re-challenging, as observed by decreased clinical and postmortem scores, besides reduced circulating lymp...Continue Reading

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Citations

Jul 13, 2016·Mediators of Inflammation·Patrícia Reis de SouzaCristina Ribeiro de Barros Cardoso
Mar 31, 2017·International Journal of Molecular Medicine·Chitraporn KuanpraditScott F Cummins
Sep 25, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Francisca Adilfa de Oliveira GarciaJohn H McNeill
Aug 27, 2021·Frontiers in Immunology·Paulo José BassoCristina Ribeiro de Barros Cardoso

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