Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats.

Journal of Clinical Biochemistry and Nutrition
Gadham Setty Saayi KrushnaLakshmi Devi Kodidhela

Abstract

Myocardial infarction is a major public health concern and the leading cause of death throughout the world. The present study investigates the ability of Aegle marmelos fruit extract to prevent pathological changes and oxidative stress after isoproterenol induced myocardial infarction in rats. In vitro studies showed that Aegle marmelos fruit extract possesses antioxidant activity. Administration of isoproterenol (85 mg/kg body weight) to rats resulted in significantly elevated plasma transaminases, lactate dehydrogenase and creatine kinase, however, cardiac tissue analyses showed decreased activity of the above enzymes compared to experimental control rats. Further, isoproterenol administration significantly increased plasma and cardiac tissue thiobarbituric acid reactive substances and lowered the activities of cardiac tissue superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and glutathione-S-transferase when compared to control groups. Pretreatment with Aegle marmelos fruit extract at a dose of 150 mg/kg body weight for a period of 45 days significantly prevented the observed alterations. Our data suggest that Aegle marmelos fruit extract exerts its protective effect by decreasing thiobarbituric aci...Continue Reading

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Citations

Nov 20, 2013·Journal of Clinical Biochemistry and Nutrition·Walid Hamdy El-TantawyEkram Nemr Abd Al Haleem
Jan 8, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Vaddi Damodara ReddyN Ch Varadacharyulu
Jun 13, 2015·Archives of Physiology and Biochemistry·Walid Hamdy El-TantawyAzza Shafei

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Methods Mentioned

BETA
light microscopy

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