Aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X: A pilot study

Brain and Behavior
Kirsten L KnakJohn Vissing

Abstract

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit. The aim was to investigate the effect of aerobic anti-gravity exercise in weak patients with CMT 1A and X. Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks. There was a significant positive difference in Berg balance scale and postural stability test between test occasions, and walking distance in the 6-min walk test trended to increase. The study indicates that the anti-gravity treadmill training of patients with CMT should be pursued in larger CMT cohorts.

References

Apr 1, 1990·Controlled Clinical Trials·W D Dupont, W D Plummer
Jan 1, 1996·Archives of Physical Medicine and Rehabilitation·N C WrightE M Bernauer
Mar 21, 2008·Seminars in Neurology·Agnes Jani-AcsadiMichael E Shy
Jun 18, 2011·American Journal of Physical Medicine & Rehabilitation·Giovanni MaggiAngelo Schenone
Apr 2, 2014·Neuromuscular Disorders : NMD·Martin Peter BerthelsenBente Rona Jensen
May 27, 2015·Journal of the Peripheral Nervous System : JPNS·Amy D SmanJoshua Burns

❮ Previous
Next ❯

Citations

Jul 25, 2019·International Journal of Molecular Sciences·Jonathan MorenaJ Chad Hoyle
Nov 27, 2021·Expert Review of Cardiovascular Therapy·Gabriela Barroso de Queiroz DavoliTim Takken

❮ Previous
Next ❯

Software Mentioned

PS Power and Size Calculation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The European Respiratory Journal
G G Riario Sforza, C Incorvaia
Journal of Physiotherapy
Stephen Downs
Southern Medical Journal
J B Thomison
Physical Therapy
T Stevenson
© 2022 Meta ULC. All rights reserved