Aerobic capacity and growth hormone deficiency after traumatic brain injury.

The Journal of Clinical Endocrinology and Metabolism
K A MossbergRandall J Urban

Abstract

GH deficiency occurs in approximately 20% of all individuals who suffer from a moderate to severe traumatic brain injury. This study determined whether GH deficiency secondary to traumatic brain injury had an effect on aerobic capacity. Subjects were screened for GH deficiency by the glucagon stimulation test and performed a maximal treadmill exercise test. Patients were studied in the postacute recovery phase after traumatic brain injury. Thirty-five individuals were studied. Groups were formed as follows: normal GH axis, greater than 8 ng/ml response (n = 12); insufficient, GH 3-8 ng/ml response (n = 11); and deficient, less than 3 ng/ml response (n = 12). There was no intervention. Aerobic capacity was assessed by measuring expired gases during a graded treadmill exercise test. One-way and two-way ANOVAs were carried out on all peak and submaximal cardiorespiratory variables, respectively. Appropriate post hoc comparisons followed as necessary. Significantly higher peak oxygen consumption was found in traumatic brain injury subjects with GH normal vs. GH insufficient and deficient [26.4 +/- 6.9, 20.8 +/- 4.6, and 19.7 +/- 5.0, respectively (P < 0.05)]. Submaximal oxygen consumption was significantly higher in the GH normal g...Continue Reading

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Citations

May 18, 2010·The Journal of Head Trauma Rehabilitation·Kurt A MossbergBrent E Masel
Aug 5, 2015·Journal of Clinical Medicine·Marianne Klose, Ulla Feldt-Rasmussen
Feb 26, 2014·Brain Injury : [BI]·Dennis J ZgaljardicMelinda Sheffield-Moore
Oct 13, 2009·Medicina clínica·Alfonso Leal-CerroUNKNOWN Sociedad Española de Endocrinología y Nutrición (SEEN)
Dec 20, 2015·Neuropsychological Rehabilitation·Brent E MaselJack Forman
Feb 20, 2018·Frontiers in Endocrinology·Mark Quinn, Amar Agha
Mar 30, 2018·Journal of the Endocrine Society·Yasufumi SekiAtsuhiro Ichihara
Sep 9, 2017·Nature Reviews. Endocrinology·Marianne Klose, Ulla Feldt-Rasmussen
Apr 2, 2019·Irish Journal of Medical Science·Oratile Kgosidialwa, Amar Agha
May 8, 2015·Endocrine Reviews·Fatih TanriverdiFahrettin Kelestimur
Aug 30, 2017·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Dean M CordingleyMichael J Ellis
Dec 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Sean H P P RoerinkAd R M M Hermus
Jul 10, 2019·International Journal of Molecular Sciences·Oratile KgosidialwaAmar Agha
Jan 15, 2019·Pituitary·Aysa HaciogluFatih Tanriverdi

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