Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis

The Journal of Physiology
E Matthew MorrisJohn P Thyfault

Abstract

Low intrinsic aerobic capacity is associated with increased all-cause and liver-related mortality in humans. Low intrinsic aerobic capacity in the low capacity runner (LCR) rat increases susceptibility to acute and chronic high-fat/high-sucrose diet-induced steatosis, without observed increases in liver inflammation. Addition of excess cholesterol to a high-fat/high-sucrose diet produced greater steatosis in LCR and high capacity runner (HCR) rats. However, the LCR rat demonstrated greater susceptibility to increased liver inflammatory and apoptotic markers compared to the HCR rat. The progressive non-alcoholic fatty liver disease observed in the LCR rats following western diet feeding was associated with further declines in liver fatty acid oxidation and mitochondrial respiratory capacity compared to HCR rats. Low aerobic capacity increases risk for non-alcoholic fatty liver disease and liver-related disease mortality, but mechanisms mediating these effects remain unknown. We recently reported that rats bred for low aerobic capacity (low capacity runner; LCR) displayed susceptibility to high fat diet-induced steatosis in association with reduced hepatic mitochondrial fatty acid oxidation (FAO) and respiratory capacity compared...Continue Reading

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Citations

Dec 6, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ashley E ArcherPaige C Geiger
Jul 24, 2018·Expert Review of Gastroenterology & Hepatology·Ludovico AbenavoliAntonino De Lorenzo
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May 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Logan K TownsendDavid C Wright

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