Aerobic endurance training status affects lymphocyte apoptosis sensitivity by induction of molecular genetic adaptations

Brain, Behavior, and Immunity
Katharina AlackFrank-Christoph Mooren

Abstract

Apoptosis is a genetically regulated form of programmed cell death which promotes the elimination of potentially detrimental immune cells. However, exercise-associated apoptosis is thought to induce a temporarily decline of the adaptive immune competence in the early post-exercise period. The purpose of the present study was to investigate if the aerobic endurance training status affects the sensitivity of human peripheral blood lymphocytes towards different types of apoptosis inducers and secondly, if this is mediated by the modulation of apoptosis-associated proteins and microRNAs. Collected at resting conditions, isolated lymphocytes of endurance trained athletes (ET) and healthy untrained subjects were either exposed to phytohemagglutinin-L (PHA-L), hydrogen peroxide (H2O2), or dexamethasone (DEX) as apoptosis inducer. Results revealed no significant differences between ET and UT in terms of lymphocyte apoptosis immediately following isolation as determined by flow cytometry using annexin V staining. After 24 h of ex vivo cultivation, lymphocytes of ET showed a reduced sensitivity to PHA-L-induced lymphocyte apoptosis which was accompanied by a noticeably up-regulation of the prominent apoptosis inhibitor genes X-linked inh...Continue Reading

References

Oct 1, 1994·International Journal of Sports Medicine·D C Nieman
Mar 21, 2001·Cell·S J RiedlG S Salvesen
Sep 9, 2004·Medicine and Science in Sports and Exercise·Frank C MoorenKlaus Völker
Aug 31, 2006·European Journal of Applied Physiology·E M PetersA A Chuturgoon
Apr 17, 2007·International Journal of Sports Medicine·L Hoffman-Goetz, P A Spagnuolo
Sep 22, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James Wilfred NavaltaZachary J Callahan
Oct 10, 2009·European Journal of Applied Physiology·Jong-Shyan Wang, Chia-Te Lin
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
Oct 5, 2010·Brain, Behavior, and Immunity·Jong-Shyan WangTzu-Pin Weng
Dec 25, 2010·Cell·Inge VerbruggeMark J Smyth
Jul 30, 2011·The International Journal of Biochemistry & Cell Biology·Lei-lei FuJin-ku Bao
Oct 1, 2011·Cell Death and Differentiation·T KaufmannP J Jost
Feb 5, 2013·Cold Spring Harbor Perspectives in Biology·J Marie Hardwick, Lucian Soane
Dec 24, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Frank C MoorenThomas Thum
Aug 19, 2014·Nature Reviews. Immunology·Georg Gasteiger, Alexander Y Rudensky
Oct 15, 2014·EMBO Reports·Bennett G ChildsJan M van Deursen
Mar 3, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tammy YauTzi Bun Ng
Apr 22, 2015·Oncotarget·Zhenyi SuQiang Yu
May 30, 2015·Journal of Applied Physiology·Frank C Mooren, Karsten Krüger
Sep 16, 2016·Cell Biology International·Tetiana KochubeiLyubov Lukash

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Citations

Feb 12, 2020·International Journal of Sports Physiology and Performance·Michal BotekBarbora Sládečková

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis