Aerobic exercise plus weight loss improves insulin sensitivity and increases skeletal muscle glycogen synthase activity in older men

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Alice S RyanHeidi K Ortmeyer

Abstract

The purpose of this study was to determine the effects of 6-month aerobic exercise training + weight loss (AEX + WL) on basal and insulin activation of glycogen synthase, basal citrate synthase activity, and Akt and AS160 phosphorylation in older, overweight/obese insulin-resistant men (n = 14; 63 ± 2 years; body mass index, 32 ± kg/m(2)). Muscle samples of the vastus lateralis were collected before and during a 3-hour 80 mU/m(2)/min hyperinsulinemic-euglycemic clamp. AEX + WL increased VO2max by 11% (p < .05) and decreased body weight (-9%, p < .001). AEX + WL increased basal citrate synthase activity by 46% (p < .01) and insulin activation of independent (2.9-fold) and fractional (2.3-fold) activities (both p < .001) of glycogen synthase. AEX + WL had no effect on phosphorylation of Akt or AS160. Glucose utilization (M) improved 25% (p < .01), and the change tended to be related to the increase in insulin activation of glycogen synthase fractional activity (r = .50, p = .08) following AEX + WL. In summary, AEX + WL has a robust effect on insulin activation of skeletal muscle glycogen synthase activity that likely contributes to improved glucose utilization in older insulin-resistant men.

References

Oct 1, 1976·Journal of Applied Physiology·E A McGuireM Berman
Apr 30, 2002·Metabolism: Clinical and Experimental·Alain GolayJean-Pierre Felber
Mar 15, 2003·The Journal of Biological Chemistry·Hiroyuki SanoGustav E Lienhard
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
May 25, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cynthia M FerraraAlice S Ryan
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Alice H LichtensteinJudith Wylie-Rosett
Jun 9, 2010·The Korean Journal of Internal Medicine·Kangduk Choi, Young-Bum Kim
Apr 21, 2011·American Journal of Physiology. Endocrinology and Metabolism·Niels JessenLaurie J Goodyear
Sep 7, 2011·Annals of Internal Medicine·Jared P ReisArthur Schatzkin
Jan 4, 2012·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Apr 7, 2016·BBA Clinical·María M Adeva-AndanyEva Ameneiros-Rodríguez
May 13, 2015·International Journal of Clinical Practice·W BouazizT Vogel
May 12, 2016·Physiological Reports·Heidi K OrtmeyerKrisAnn K Oursler
Jun 17, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Alice S Ryan, Heidi K Ortmeyer

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