Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium

Journal of Cardiovascular Translational Research
Ying CaiSui-Xin Liu

Abstract

Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we investigated the effects of the miR-492/resistin axis on improving endothelial injury in ApoE-/- mice (ApoE-deficient/knockout in C57BL/6 mice) through swimming exercises. Our results showed that the severity of AS and insulin resistance (IR) in these mice were significantly reduced by swimming exercises. In addition, miR-492 expression in the aortic endothelium of ApoE-/- mice was decreased, in addition to increased levels of resistin. Interestingly, swimming exercises increased miR-492 expression while decreasing that of resistin. Taken together, swimming exercises delayed the progression of AS, possibly by upregulating miR-492 and downregulating resistin in aortic endothelium. Therefore, exercises modulated glucose and lipid metabolism, alleviated endothelial IR, and repaired endothelial injury.

References

Mar 1, 1984·Progress in Cardiovascular Diseases·N B Ruderman, C Haudenschild
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y NakashimaR Ross
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·Y NakashimaR Ross
Mar 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Byoung MoonNajma Begum
Oct 9, 2004·Endocrinology·Naoichi SatoHajime Nawata
Mar 9, 2005·Biochemical and Biophysical Research Communications·Jing TianWeibin Shi
Mar 9, 2005·Endocrinology and Metabolism Clinics of North America·David M Kendall
Sep 3, 2005·FEBS Letters·Rengasamy Palanivel, Gary Sweeney
Jul 20, 2006·Blood·Laura PolisenoGiuseppe Rainaldi
May 26, 2007·Endocrine Reviews·Ranganath MuniyappaMichael J Quon
Jan 16, 2008·Journal of Zhejiang University. Science. B·You LiuShao-hong Chen
Oct 8, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Elin Ekblom-BakBjörn Ekblom
Feb 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Vincent J de BeerDaphne Merkus
Jul 28, 2011·British Journal of Sports Medicine·Lars Bo AndersenAndrew Hills
Jan 12, 2013·Reviews in Endocrine & Metabolic Disorders·Ranganath Muniyappa, James R Sowers
May 25, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Akifumi KushiyamaTomoichiro Asano
Jun 28, 2013·Journal of Cellular and Molecular Medicine·Francesca PatellaGiuseppe Rainaldi
Sep 12, 2013·International Journal of Sports Medicine·X-D WuY-Q Chen
Nov 2, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Jie-Mei WangAlex F Chen
Mar 20, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Stéphano F S MeloEdilamar M Oliveira
Dec 17, 2014·International Journal of Cardiology·Feng TianJia-rui Hu

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Citations

Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Patricia MarchioMaria D Mauricio
Jan 4, 2019·Journal of Cardiovascular Translational Research·Minjun XuJunjie Xiao
Jan 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Gurneet S SanghaAlisa M Clyne
Apr 11, 2021·Npj Regenerative Medicine·Hongyun WangJunjie Xiao
Sep 18, 2021·Journal of Cardiovascular Translational Research·Juan GaoJunjie Xiao

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