Aerobic fitness, muscular strength and obesity in relation to risk of heart failure

Heart
Casey CrumpKristina Sundquist

Abstract

Low physical fitness and obesity have been associated with higher risk of developing heart failure (HF), but their interactive effects are unknown. Elucidation of interactions among these common modifiable factors may help facilitate more effective primary prevention. We conducted a national cohort study to examine the interactive effects of aerobic fitness, muscular strength and body mass index (BMI) among 1 330 610 military conscripts in Sweden during 1969-1997 (97%-98% of all 18-year-old men) on risk of HF identified from inpatient and outpatient diagnoses through 2012 (maximum age 62 years). There were 11 711 men diagnosed with HF in 37.8 million person-years of follow-up. Low aerobic fitness, low muscular strength and obesity were independently associated with higher risk of HF, after adjusting for each other, socioeconomic factors, other chronic diseases and family history of HF. The combination of low aerobic fitness and low muscular strength (lowest vs highest tertiles) was associated with a 1.7-fold risk of HF (95% CI 1.6 to 1.9; p<0.001; incidence rates per 100 000 person-years, 43.2 vs 10.8). These factors had positive additive and multiplicative interactions (p<0.001) and were associated with increased risk of HF ev...Continue Reading

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Citations

Apr 25, 2019·Heart Failure Reviews·Anna WawrzeńczykJacek Budzyński
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Casey CrumpKristina Sundquist
Jan 10, 2021·Advances in Rheumatology·Alexandre Moura Dos SantosSamuel Katsuyuki Shinjo
Feb 1, 2021·The Journal of Pediatrics·Lindsay R PoolNorrina B Allen
Jan 13, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Chun-Ping Huang, Wei-Liang Chen
Apr 6, 2021·JAMA Pediatrics·Casey CrumpKristina Sundquist

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