Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice

ENeuro
Richard A HarrisRobert C Cumming

Abstract

The consolidation of newly formed memories and their retrieval are energetically demanding processes. Aerobic glycolysis (AG), also known as the Warburg effect, consists of the production of lactate from glucose in the presence of oxygen. The astrocyte neuron lactate shuttle hypothesis posits that astrocytes process glucose by AG to generate lactate, which is used as a fuel source within neurons to maintain synaptic activity. Studies in mice have demonstrated that lactate transport between astrocytes and neurons is required for long-term memory formation, yet the role of lactate production in memory acquisition and retrieval has not previously been explored. Here, we examined the effect of dichloroacetate (DCA), a chemical inhibitor of lactate production, on spatial learning and memory in mice using the Morris water maze (MWM). In vivo hyperpolarized 13C-pyruvate magnetic resonance spectroscopy revealed decreased conversion of pyruvate to lactate in the mouse brain following DCA administration, concomitant with a reduction in the phosphorylation of pyruvate dehydrogenase. DCA exposure before each training session in the MWM impaired learning, which subsequently resulted in impaired memory during the probe trial. In contrast, mi...Continue Reading

Citations

Aug 23, 2019·NMR in Biomedicine·Lydia M Le PageMyriam M Chaumeil
Jun 6, 2020·Frontiers in Neuroscience·Shayne Mason
Feb 24, 2021·Cell Calcium·Anemari HorvatNina Vardjan
May 18, 2021·Frontiers in Pharmacology·Charles FinsterwaldSylvain Lengacher
Aug 27, 2021·Metabolites·María Fernanda Veloz CastilloCorrado Calì

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Methods Mentioned

BETA
FRET
biosensors
transgenic

Software Mentioned

maze
Quantity One
ANY
RStudio

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